The activity of peptides of the calcitonin family in bone

D Naot, DS Musson, J Cornish - Physiological reviews, 2019 - journals.physiology.org
Calcitonin was discovered over 50 yr ago as a new hormone that rapidly lowers circulating
calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as …

The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism

D Naot, J Cornish - Bone, 2008 - Elsevier
The 'calcitonin family'is a group of peptide hormones that share structural similarities with
calcitonin, and includes calcitonin gene-related peptide (CGRP), amylin, adrenomedullin …

Calcitonin and bone physiology: in vitro, in vivo, and clinical investigations

J Xie, J Guo, Z Kanwal, M Wu, X Lv… - International Journal …, 2020 - Wiley Online Library
Calcitonin was discovered as a peptide hormone that was known to reduce the calcium
levels in the systemic circulation. This hypocalcemic effect is produced due to multiple …

Forty years of calcitonin—where are we now? A tribute to the work of Iain Macintyre, FRS

M Zaidi, AM Inzerillo, BS Moonga, PJR Bevis… - Bone, 2002 - Elsevier
Calcitonin was discovered as a hypocalcemic principal that was initially thought to originate
from the parathyroid gland. This view was corrected subsequently, and an origin from the …

Effects of peptides from the calcitonin genes on bone and bone cells

M Zaidi, PJR Bevis, JL Beacham… - Quarterly Journal of …, 1988 - Wiley Online Library
The calcitonin‐calcitonin gene‐related peptide (CGRP) gene complex encodes a family of
novel peptides‐calcitonin, CGRP and katacalcin. Whereas calcitonin is a circulating …

Calcitonin gene-related peptide inhibits osteoclastic bone resorption: a comparative study

M Zaidi, K Fuller, PJR Bevis, RE GainesDas… - Calcified tissue …, 1987 - Springer
Besides the calcitonin (CT) precursor, the calcitonin gene also encodes another peptide—
calcitonin gene-related peptide (CGRP). We have previously reported that CGRP lowers …

A direct action of human calcitonin gene-related peptide on isolated osteoclasts

M Zaidi, TJ Chambers, REG Das… - Journal of …, 1987 - joe.bioscientifica.com
The calcitonin gene encodes a small family of peptides: calcitonin, calcitonin gene-related
peptide (CGRP) and katacalcin. Whereas calcitonin is concerned with skeletal maintenance …

[PDF][PDF] Deletions of genes encoding calcitonin/a-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors …

UH Lerner - J Musculoskelet Neuronal Interact, 2006 - ismni.org
It has been suggested that skeletal nerve fibers may play important roles in neuro-
osteogenic interactions. This view is partly based upon information obtained from …

Calcitonin: physiology or fantasy?

RA Davey, DM Findlay - Journal of Bone and Mineral Research, 2013 - academic.oup.com
Calcitonin, a potent hypocalcemic hormone produced by the C‐cells of the thyroid, was first
discovered by Harold Copp in 1962. The physiological significance of calcitonin has been …

Human Synthetic Calcitonin Gene-Related Peptide Inhibits Bone Resorption in Vitro

SM D'SOUZA, I MacIntyre, SI Girgis, GR Mundy - Endocrinology, 1986 - academic.oup.com
The calcitonin gene-related peptide (CGRP) is a pepticle which normally circulates. It is
encoded by the calcitonin gene, whose precise function is unknown. Since it has recently …