Patients with germline SDHD pathogenic variants (encoding succinate dehydrogenase
subunit D; ie, paraganglioma 1 syndrome) are predominantly affected by head and neck …

Adult and paediatric patients with pathogenic variants in the gene encoding succinate
dehydrogenase (SDH) subunit B (SDHB) often have locally aggressive, recurrent or …

ContextGermline mutations of the genes encoding succinate dehydrogenase subunits B
(SDHB) and D (SDHD) predispose to paraganglioma syndromes type 4 (PGL-4) and type 1 …

Background Phaeochromocytomas and paragangliomas are neuro-endocrine tumours that
occur sporadically and in several hereditary tumour syndromes, including the …

Context Paraganglioma (PGL) has the highest degree of heritability among human
neoplasms. Current clinical understanding of germline SDHA mutation carriers is limited …

Context: Germline mutations in SDHx genes cause hereditary paraganglioma. Objective:
The aim of the study was to assess the indications for succinate dehydrogenase (SDH) …

Context: The identification of mutations in genes encoding peptides of succinate
dehydrogenase (SDH) in pheochromocytoma/paraganglioma syndromes has necessitated …

Objective Head and neck paragangliomas (HNPGL) are associated with mutations in genes
encoding subunits of succinate dehydrogenase (SDH). The aim of this study was to evaluate …

We recently read with interest the article by Ricketts and colleagues [2010] based on a
genotype–phenotype association study performed in a very large number of germline SDHB …

Objective Hereditary paraganglioma (PGL) syndromes result from germline mutations in
genes encoding subunits B, C and D of the mitochondrial enzyme succinate dehydrogenase …