To get insight into the mechanisms that may lead to progression of temporal lobe epilepsy,
we investigated gene expression during epileptogenesis in the rat. RNA was obtained from …

Symptomatic temporal lobe epilepsy typically develops in three phases: brain insult→
latency period (epileptogenesis)→ recurrent seizures (epilepsy). We hypothesized that …

The “latent period” between brain injury and clinical epilepsy is widely regarded to be a
seizure-free, pre-epileptic state during which a time-consuming cascade of molecular events …

Neither the molecular basis of the pathologic tendency of neuronal circuits to generate
spontaneous seizures (epileptogenicity) nor anti-epileptogenic mechanisms that maintain a …

Epileptogenesis refers to a phenomenon in which the brain undergoes molecular and
cellular alterations after a brain‐damaging insult, which increase its excitability and …

The biology underlying epileptic brain activity in humans is not well understood and likely
depends on changes in gene expression. We performed a microarray transcriptome profiling …

There are no pharmacological interventions to prevent the development of epilepsy,
although many promising compounds have been identified in the animal laboratory. Clinical …

Epileptic activity evokes profound alterations of hippocampal organization and function.
Genomic responses may reflect immediate consequences of excitatory stimulation as well …

The main goal of this study was to identify common features in the molecular response to
epileptogenic stimuli across different animal models of epileptogenesis. Therefore, we …

Objective Because brain inflammation may contribute to the pathophysiology of temporal
lobe epilepsy (TLE), we investigated the expression of various inflammatory markers of the …