Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with
enhanced inflammatory response. However, whether inflammatory signaling is causally …

Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia,
affects millions of people worldwide. AF is associated with common risk factors, including …

Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …

Inflammasomes are high molecular weight protein complexes in the cytosol of immune and
other cells that play a critical role in the innate immune system in response to cellular stress …

While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in
physiological cardiac aging is largely unknown. During aging, many alterations occur in the …

Background: Obesity, characterized by systemic low-grade inflammation, is considered a
well-known risk for atrial fibrillation. In fact, IL-10 (interleukin 10), which is a potent anti …

Chronic kidney disease (CKD) is associated with a higher risk of atrial fibrillation (AF). The
mechanistic link between CKD and AF remains elusive. IL-1β, a main effector of NLR family …

Background: Mechanical stress on the heart, such as high blood pressure, initiates
inflammation and causes hypertrophic heart disease. However, the regulatory mechanism of …