Neurobiological bases of autism–epilepsy comorbidity: a focus on excitation/inhibition imbalance

Y Bozzi, G Provenzano… - European Journal of …, 2018 - Wiley Online Library
Autism spectrum disorders (ASD) and epilepsy are common neurological diseases of
childhood, with an estimated incidence of approximately 0.5–1% of the worldwide …

Autism, epilepsy, and synaptopathies: a not rare association

R Keller, R Basta, L Salerno, M Elia - Neurological Sciences, 2017 - Springer
Autism spectrum disorders (ASD) are neurodevelopmental disorders typically diagnosed in
childhood, characterized by core social dysfunction, rigid and repetitive behaviors, restricted …

Cortical interneuron dysfunction in epilepsy associated with autism spectrum disorders

J Jacob - Epilepsia, 2016 - Wiley Online Library
Autism and epilepsy are two associated disorders that are highly prevalent, share common
developmental origins, and demonstrate substantial heritability. In this review, cross …

Autism spectrum disorder and epilepsy: two sides of the same coin?

SS Jeste, R Tuchman - Journal of child neurology, 2015 - journals.sagepub.com
Autism spectrum disorders and epilepsy commonly co-occur. In this review, we consider
some unresolved questions regarding the temporal relationship, causal mechanisms, and …

Epilepsy and autism: neurodevelopmental perspective

R Tuchman, M Cuccaro - Current neurology and neuroscience reports, 2011 - Springer
Epilepsy and autism coexist in up to 20% of children with either disorder. Current studies
suggest that a frequent co-occurring condition in epilepsy and autism is intellectual …

Autism and epilepsy: historical perspective

R Tuchman, M Cuccaro, M Alessandri - Brain and Development, 2010 - Elsevier
Autism spectrum disorders (ASD) and epilepsy co-occur in approximately 30% of individuals
with either ASD or epilepsy. While there is no single unifying ASD–epilepsy phenotype …

[HTML][HTML] Multiplex gene and phenotype network to characterize shared genetic pathways of epilepsy and autism

J Peng, Y Zhou, K Wang - Scientific reports, 2021 - nature.com
It is well established that epilepsy and autism spectrum disorder (ASD) commonly co-occur;
however, the underlying biological mechanisms of the co-occurence from their genetic …

Autism spectrum disorder and epilepsy: disorders with a shared biology

BH Lee, T Smith, AR Paciorkowski - Epilepsy & Behavior, 2015 - Elsevier
There is an increasing recognition of clinical overlap in patients presenting with epilepsy
and autism spectrum disorder (ASD), and a great deal of new information regarding the …

[HTML][HTML] Characterizing the interplay between autism spectrum disorder and comorbid medical conditions: An integrative review

C Tye, AK Runicles, AJO Whitehouse… - Frontiers in …, 2019 - frontiersin.org
Co-occurring medical disorders and associated physiological abnormalities in individuals
with autism spectrum disorder (ASD) may provide insight into causal pathways or underlying …

Epilepsy and autism spectrum disorders: are there common developmental mechanisms?

A Brooks-Kayal - Brain and Development, 2010 - Elsevier
Autistic spectrum disorders (ASD) and epilepsies are heterogeneous disorders that have
diverse etiologies and pathophysiologies. The high rate of co-occurrence of these disorders …