The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo

Y Chen, W Yang, X Shi, C Zhang, G Song… - Frontiers in cell and …, 2020 - frontiersin.org
Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an
innermost oocyte and several surrounding flattened granulosa cells. Unlike males …

Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood

H Zhang, K Liu - Human reproduction update, 2015 - academic.oup.com
BACKGROUND The first small follicles to appear in the mammalian ovaries are primordial
follicles. The initial pool of primordial follicles serves as the source of developing follicles …

Current understandings of core pathways for the activation of mammalian primordial follicles

Y Zhao, H Feng, Y Zhang, JV Zhang, X Wang, D Liu… - Cells, 2021 - mdpi.com
The mammalian ovary has two main functions—producing mature oocytes for fertilization
and secreting hormones for maintaining the ovarian endocrine functions. Both functions are …

Regulation of primordial follicle formation, dormancy, and activation in mice

G Nagamatsu - Journal of Reproduction and Development, 2021 - jstage.jst.go.jp
In female reproduction, the oocyte number is limited after birth. To achieve a continuous
ovulatory cycle, oocytes are stored in primordial follicles. Therefore, the regulation of …

Molecular mechanisms underlying the activation of mammalian primordial follicles

D Adhikari, K Liu - Endocrine reviews, 2009 - academic.oup.com
In humans and other mammalian species, the pool of resting primordial follicles serves as
the source of developing follicles and fertilizable ova for the entire length of female …

The two classes of primordial follicles in the mouse ovary: their development, physiological functions and implications for future research

W Zheng, H Zhang, K Liu - Molecular human reproduction, 2014 - academic.oup.com
Ovarian follicles are the basic functional units in the mammalian ovary. This review
summarizes early pioneering studies and focuses on recent progress that has shown that …

Primordial follicular assembly in humans–revisited

A Maheshwari, PA Fowler - Zygote, 2008 - cambridge.org
Recent interest in the initial phases of ovarian follicular formation and development has lead
to a number of publications in this area, most of which address the autocrine and paracrine …

[HTML][HTML] Control of ovarian primordial follicle activation

JY Kim - Clinical and experimental reproductive medicine, 2012 - ncbi.nlm.nih.gov
The ovarian follicles develop initially from primordial follicles. The majority of ovarian
primordial follicles are maintained quiescently as a reserve for the reproductive life span …

Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions

W Zheng, H Zhang, N Gorre, S Risal… - Human molecular …, 2014 - academic.oup.com
In the mammalian ovary, progressive activation of primordial follicles serves as the source of
fertilizable ova, and disorders in the development of primordial follicles lead to various …

Implications of nonphysiological ovarian primordial follicle activation for fertility preservation

J Grosbois, M Devos, I Demeestere - Endocrine reviews, 2020 - academic.oup.com
In recent years, ovarian tissue cryopreservation has rapidly developed as a successful
method for preserving the fertility of girls and young women with cancer or benign conditions …