The coffee components kahweol and cafestol (K/C) were reported to be protective against
mutagenic damage by heterocylic amines and aflatoxin B1 in the rat, while in humans the …

The coffee components kahweol and cafestol (K/C) have been reported to protect the colon
and other organs of the rat against the formation of DNA adducts by 2-amino-1-methyl-6 …

The coffee specific diterpenes cafestol and kahweol (C+ K) have been reported to be anti-
carcinogenic in several animal models. It has been postulated that this activity may be …

Coffee drinking has been associated with reduced incidence of colorectal cancer, possibly
via chemoprotection/modification of the metabolism of dietary heterocyclic amine …

Enzymes of xenobiotic metabolism are involved in the activation and detoxification of
carcinogens and can play a pivotal role in the susceptibility of individuals toward chemically …

The tripeptide glutathione (L-γ-glutamyl-L-cysteinylglycine) is found ubiquitous in
microorganisms, plants and animals. In mammalian cells, where the tripeptide fulfils …

A lower rate of colon cancer was observed in consumers of coffee with a high content of the
diterpenes Kahweol and Cafestol (K/C). In animal models, K/C have been found to protect …

Glutathione (GSH) is an important antioxidant and cofactor of detoxifying metabolism.
Therefore, elevation of GSH as achieved by inducing γ-glutamylcysteine synthetase (GCS) …

In vivo anti-genotoxic effects of caffeinated and decaffeinated instant coffee were compared
in mice after pretreatment either by gavage for 10 consecutive days or in the drinking water …

Epidemiological studies have found an inverse association between coffee consumption
and the risk of certain types of cancers such as colorectal cancers. Animal data support such …