Dysregulated epigenetic modifications dynamically drive the abnormal transcription process
to affect the tumor microenvironment; thus, promoting cancer progression, drug resistance …

Not only genetic but also epigenetic factors are closely associated with cancer, especially
with its malignant evolution. Cancer therapies based on epigenetic modulation have …

The tumor microenvironment (TME) is crucial to neoplastic processes, fostering proliferation,
angiogenesis and metastasis. Epigenetic regulations, primarily including DNA and RNA …

Disruption of the epigenetic program of gene expression is a hallmark of cancer that initiates
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …

Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …

The emergence of nanotechnology applied to medicine has revolutionized the treatment of
human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs …

Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …

Recent studies provide compelling evidence that epigenetic dysregulation is involved in
almost every step of tumor development and progression. Differences in tumor behavior …

Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Despite considerable scientific progress, the burden of cancer in our society remains a
major public health problem. Tumorigenesis is recognized as a complex and multistep …