Neuroinflammation is one of the most striking hallmarks of amyotrophic lateral sclerosis
(ALS). Nuclear factor-kappa B (NF-κB), a master regulator of inflammation, is upregulated in …

Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous disorder characterized by
loss of motor neurons, resulting in paralysis and death. Multiple mechanisms of motor …

Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

Increasing evidence suggests that the pathogenesis of neurodegenerative diseases
including amyotrophic lateral sclerosis (ALS) is not restricted to the neurons but attributed to …

Astrocytes are involved in non‐cell‐autonomous pathogenic cascades in amyotrophic
lateral sclerosis (ALS); however, their role is still debated. We show that astrocytic NF‐κB …

There is increasing evidence that oxidative damage plays a major role in amyotrophic lateral
sclerosis (ALS), but how it contributes to motor neuron degeneration and astrocytic gliosis …

Microglia are the primary immune cells of the CNS, carrying out key homeostatic roles and
undergoing context-dependent and temporally regulated changes in response to injury and …

Neuroinflammation is a prominent pathological feature in the spinal cords of patients with
amyotrophic lateral sclerosis (ALS), as well as in transgenic mouse models of inherited ALS …

Background The role of neuroinflammation in motor neuron death of amyotrophic lateral
sclerosis (ALS) is unclear. The human mutant superoxide dismutase-1 (hmSOD1) …

Microglia and peripheral macrophages have both been implicated in amyotrophic lateral
sclerosis (ALS), although their respective roles have yet to be determined. We now show …