This report highlights the first biochemical characterization of a multi-domain biosynthetic
enzyme for basidiomycete secondary metabolism: the tri-domain enzyme atromentin …

Non-ribosomal peptide synthetase (NRPS)-like enzymes catalyze the non-oxidative
homodimerization of aromatic α-keto acids, but the exact reaction mechanism is unknown …

Background The terphenylquinones represent an ecologically remarkable class of
basidiomycete natural products as they serve as central precursors of pigments and …

Notoamide S has been hypothesized to be a key biosynthetic intermediate for characteristic
metabolites stephacidin A, notoamide B, and versicolamide B in Aspergillus sp. but has not …

The asterriquinones represent a class of ascomycete metabolic products whose significance
stems from remarkable and useful pharmacological activities, among those antiretroviral (eg …

Basidiomycete fungi are characterized ecologically for their vital functional role in ecosystem
carbon recycling and chemically for their capacity to produce a diverse array of small …

The polyketide chains of the two ansamycin antibiotics, ansatrienin (mycotrienin) and
naphthomycin produced by Streptomyces collinus are assembled using 3‐amino‐5 …

The RNA polymerase inhibitor tiacumicin B is currently undergoing phase III clinical trial for
treatment of Clostridium difficile associated diarrhea with great promise. To understand the …

Pradimicins are potent antifungal antibiotics having an unusual dihydrobenzo [$\alpha $]
naphthacenequinone aglycone substituted with D-alanine and sugars. Pradimicins are …

Epipolythiodioxopiperazines (ETPs) are a class of fungal secondary metabolites derived
from diketopiperazines. Acetylaranotin belongs to one structural subgroup of ETPs …