Therapeutic potential of toleragens in the management of antiphospholipid syndrome

KA Cockerill, GM Iverson, DS Jones, MD Linnik - BioDrugs, 2004 - Springer
Autoantibodies to β2-glycoprotein I (β2GPI) are believed to be the primary cause of
coagulation abnormalities in patients with antiphospholipid syndrome (APS). Clinical …

14th international congress on antiphospholipid antibodies task force report on antiphospholipid syndrome treatment trends

D Erkan, CL Aguiar, D Andrade, H Cohen… - Autoimmunity …, 2014 - Elsevier
Antiphospholipid Syndrome (APS) is characterized by vascular thrombosis and/or
pregnancy morbidity occurring in patients with persistent antiphospholipid antibodies (aPL) …

Emerging therapies in antiphospholipid syndrome

D Andrade, M Tektonidou - Current rheumatology reports, 2016 - Springer
Antiphospholipid syndrome (APS) is a hypercoagulable state characterized by arterial and
venous thromboses and pregnancy morbidity in the presence of antiphospholipid …

Pathophysiology of thrombosis and potential targeted therapies in antiphospholipid syndrome

O Amengual, T Atsumi, T Koike - Current Vascular …, 2011 - ingentaconnect.com
The antiphospholipid syndrome (APS) is an autoimmune disease in which recurrent
vascular thrombosis, pregnancy morbidity or a combination of these events is associated …

Antiphospholipid antibodies and the antiphospholipid syndrome: from coagulation to the clinic

R Selby, J Abdulrehman - The Journal of Applied Laboratory …, 2022 - academic.oup.com
Antiphospholipid syndrome (APS) is a systemic, autoimmune disorder characterized by the
presence of antiphospholipid antibodies (APLA) directed to various plasma proteins bound …

Current insights into the “antiphospholipid” syndrome: clinical, immunological, and molecular aspects

DA Kandiah, A Sali, Y Sheng, EJ Victoria… - Advances in …, 1998 - Elsevier
Publisher Summary Antiphospholipid (aPL) antibodies are found in normal individuals, and
can be divided into two main groups, classified according to their association with …

Anti-phospholipid syndrome: from patient's bedside to experimental animal models and back to the patient's bedside.

L Ziporen, Y Shoenfeld - Hematology and cell therapy, 1998 - europepmc.org
The availability of animal models of the APS has provided a lot of experimental data which
might be considered in trying to unravel several questions concerning this complicated …

[PDF][PDF] Pathophysiology of antiphospholipid antibodies

PG De Groot, RH Derksen - Neth J Med, 2004 - njmonline.nl
The presence of antiphospholipid antibodies in plasma is a risk factor for thromboembolic
complications. In vitro, however, the same antibodies can prolong clotting times in …

The future of antiphospholipid antibody testing

PG de Groot, RT Urbanus - Seminars in thrombosis and …, 2012 - thieme-connect.com
The presence of antiphospholipid antibodies (aPL) is essential to diagnose the
antiphospholipid syndrome (APS). Three assays are available to detect the presence of …

[HTML][HTML] Pathogenesis of the antiphospholipid syndrome revisited: time to challenge the dogma

KJ Lackner, N Müller‐Calleja - Journal of Thrombosis and Haemostasis, 2016 - Elsevier
For more than a decade the antiphospholipid syndrome (APS) has been reported to be
caused mainly by antiphospholipid antibodies (aPL), which are not directed against …