Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements
Analyses of genetic variation in many taxa have established that neutral genetic diversity is
shaped by natural selection at linked sites. Whether the mode of selection is primarily the …
shaped by natural selection at linked sites. Whether the mode of selection is primarily the …
A quantitative genetic model of background selection in humans
Author summary Across the human genome, there are large-scale fluctuations in genetic
diversity caused by the indirect effects of selection. This “linked selection signal” reflects the …
diversity caused by the indirect effects of selection. This “linked selection signal” reflects the …
Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome
KE Lohmueller, A Albrechtsen, Y Li, SY Kim… - PLoS …, 2011 - journals.plos.org
A major question in evolutionary biology is how natural selection has shaped patterns of
genetic variation across the human genome. Previous work has documented a reduction in …
genetic variation across the human genome. Previous work has documented a reduction in …
Fitting background-selection predictions to levels of nucleotide variation and divergence along the human autosomes
FA Reed, JM Akey, CF Aquadro - Genome research, 2005 - genome.cshlp.org
The roles of positive directional selection (selective sweeps) and negative selection
(background selection) in shaping the genome-wide distribution of genetic variation in …
(background selection) in shaping the genome-wide distribution of genetic variation in …
Natural selection at linked sites in humans
BA Payseur, MW Nachman - Gene, 2002 - Elsevier
Theoretical and empirical work indicates that patterns of neutral polymorphism can be
affected by linked, selected mutations. Under background selection, deleterious mutations …
affected by linked, selected mutations. Under background selection, deleterious mutations …
A new test suggests hundreds of amino acid polymorphisms in humans are subject to balancing selection
The role that balancing selection plays in the maintenance of genetic diversity remains
unresolved. Here, we introduce a new test, based on the McDonald–Kreitman test, in which …
unresolved. Here, we introduce a new test, based on the McDonald–Kreitman test, in which …
[HTML][HTML] A general model of the relationship between the apportionment of human genetic diversity and the apportionment of human phenotypic diversity
MD Edge, NA Rosenberg - Human biology, 2015 - ncbi.nlm.nih.gov
Abstract Models that examine genetic differences between populations alongside a
genotype–phenotype map can provide insight about phenotypic variation among groups …
genotype–phenotype map can provide insight about phenotypic variation among groups …
Selection plays the hand it was dealt: evidence that human adaptation commonly targets standing genetic variation
Selection plays the hand it was dealt: evidence that human adaptation commonly targets
standing genetic variation | Genome Biology Skip to main content SpringerLink Account Menu …
standing genetic variation | Genome Biology Skip to main content SpringerLink Account Menu …
Genome-wide signals of positive selection in human evolution
The role of positive selection in human evolution remains controversial. On the one hand,
scans for positive selection have identified hundreds of candidate loci, and the genome …
scans for positive selection have identified hundreds of candidate loci, and the genome …
Selective constraint, background selection, and mutation accumulation variability within and between human populations
Background Regions of the genome that are under evolutionary constraint across multiple
species have previously been used to identify functional sequences in the human genome …
species have previously been used to identify functional sequences in the human genome …