Understanding relationships between heart failure and arrhythmias, important causes of
suffering and sudden death, remains an unmet goal for biomedical researchers and …

Many signals have risen and fallen in the tide of investigation into mechanisms of
myocardial hypertrophy and heart failure (HF). In our opinion, the multifunctional Ca and …

The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates a rich
variety of downstream targets in heart. Ca2+ homeostatic proteins are important CaMKII …

The multifunctional Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) has
emerged as a proarrhythmic and procardiomyopathic signal in a wide range of structural …

Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine
kinase expressed abundantly in the heart. CaMKII targets numerous proteins involved in …

Calcium/calmodulin (Ca2+/CaM) dependent protein kinase II (CaMKII) has emerged as a
key nodal protein in the regulation of cardiac physiology and pathology. Due to the …

Background—Calmodulin kinase (CaMK) II is linked to arrhythmia mechanisms in cellular
models where repolarization is prolonged. CaMKII upregulation and prolonged …

Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-
contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the …

Calcium/calmodulin-dependent protein kinase II (CaMKII) has emerged as key enzyme in
many cardiac pathologies, especially heart failure (HF), myocardial infarction and …

Background—Transgenic (TG) Ca/calmodulin-dependent protein kinase II (CaMKII) δC mice
have heart failure and isoproterenol (ISO)-inducible arrhythmias. We hypothesized that …