Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes
to brain damage in stroke. Here we show that tau-deficient (tau−/−) mice are profoundly …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

Background Hyperexcitability of neuronal networks can lead to excessive release of the
excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by …

Ras-GRF2 are less resistant to ischemic injury and show increased infarction after focal
cerebral ischemia. 11 The net effect of ERK activation, however, may also depend on the …

Recent findings have provided insights into pathogenic mechanism (s) that may complement
and add to the traditional glutamatergic mechanisms to which ischemic brain injury is …

Glutamate receptor-mediated excitotoxicity is thought to contribute to the development of
Alzheimer's disease (AD), but the underlying mechanism is unknown. In this study, we …

Excitotoxicity is a process observed in many disease states by which an excessive synaptic
excitation causes neuronal death, and is thought to be triggered by the extracellular …

Traumatic brain injury (TBI) is the leading cause of mortality and disability in young people
and may lead to the development of progressive neurodegeneration, such as that observed …

The role of remote astrocyte (AC) reaction to central or peripheral axonal insult is not clearly
understood. Here we use a transgenic approach to compare the direct influence of normal …

Acute secondary neuronal cell death, as seen in neurodegenerative disease, cerebral
ischemia (stroke) and traumatic brain injury (TBI), drives spreading neurotoxicity into …