[HTML][HTML] Decreased in vivo glutamate/GABA ratio correlates with the social behavior deficit in a mouse model of autism spectrum disorder
G Park, SJ Jeon, IO Ko, JH Park, KC Lee, MS Kim… - Molecular brain, 2022 - Springer
To diagnose autism spectrum disorder (ASD), researchers have sought biomarkers whose
alterations correlate with the susceptibility to ASD. However, biomarkers closely related to …
alterations correlate with the susceptibility to ASD. However, biomarkers closely related to …
Increased prefrontal GABA concentrations in adults with autism spectrum disorders
S Maier, AL Düppers, K Runge, M Dacko… - Autism …, 2022 - Wiley Online Library
The excitatory‐inhibitory imbalance hypothesis postulates dysregulation of the gamma‐
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …
[HTML][HTML] Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental syndrome with a high
human and economic burden. The pathophysiology of ASD is largely unclear, thus …
human and economic burden. The pathophysiology of ASD is largely unclear, thus …
[HTML][HTML] Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance …
L Tebartz van Elst, S Maier, T Fangmeier… - Molecular …, 2014 - nature.com
Over the last few years, awareness of autism spectrum disorder (ASD) in adults has
increased. The precise etiology of ASD is still unresolved. Animal research, genetic and …
increased. The precise etiology of ASD is still unresolved. Animal research, genetic and …
[HTML][HTML] Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited
Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate
cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 …
cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 …
Glutamate and functional connectivity-support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders
It has been proposed that the Glutamate (Glu) system is implicated in autism spectrum
disorders (ASD) via an imbalance between excitatory and inhibitory brain circuits, which …
disorders (ASD) via an imbalance between excitatory and inhibitory brain circuits, which …
[HTML][HTML] Region-specific elevations of glutamate+ glutamine correlate with the sensory symptoms of autism spectrum disorders
Individuals on the autism spectrum are often reported as being hyper-and/or hyporeactive to
sensory input. These sensory symptoms were one of the key observations that led to the …
sensory input. These sensory symptoms were one of the key observations that led to the …
[HTML][HTML] Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism
Increased excitatory neuronal tones have been implicated in autism, but its mechanism
remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic …
remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic …
[HTML][HTML] Genetics of glutamate and its receptors in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …
deficits in social interaction skills, impaired communication, and repetitive and restricted …
Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and …
The nature of neurochemical changes in autism spectrum disorder (ASD) remains
controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high …
controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high …