Background Patients with chronic limb-threatening ischemia (CLTI) require revascularization
to improve limb perfusion and thereby limit the risk of amputation. It is uncertain whether an …

Key Clinical Points Chronic Limb-Threatening Ischemia Chronic limb-threatening ischemia
typically manifests as ischemic pain in the distal leg or foot while the patient is at rest, as …

Guideline Summary Chronic limb-threatening ischemia (CLTI) is associated with mortality,
amputation, and impaired quality of life. These Global Vascular Guidelines (GVG) are …

Background Critical limb ischemia (CLI) is increasing in prevalence, and remains a
significant source of mortality and limb loss. The decision to recommend surgical or …

Background—The aim of this study was to compare clinical outcomes between surgical
reconstruction and endovascular therapy (EVT) for critical limb ischemia (CLI) in today's real …

Background Long-term results comparing percutaneous transluminal angioplasty with or
without stenting (PTA/S) and open surgical bypass for chronic limb-threatening ischemia …

Importance Chronic critical limb ischemia, marked by intractable lower extremity ischemic
rest pain and tissue loss, is a highly morbid condition that leads to the loss of ambulation …

Lower extremity critical limb ischemia (CLI) represents symptoms related to end-stage
atherosclerotic peripheral arterial disease manifested by rest pain and tissue loss. It is …

Objectives: The most effective first-line treatment between endovascular therapy and bypass
surgery for patients with critical limb ischemia (CLI) is still not well defined. The primary aim …

Background For patients with critical limb ischemia (CLI), the optimal treatment to enhance
limb preservation, prevent death, and improve functional status is unknown. We performed a …