Advances in genome editing through control of DNA repair pathways
Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …
Advancements in genome editing take advantage of these pathways to produce permanent …
The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair
M Jasin, JE Haber - DNA repair, 2016 - Elsevier
DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can
lead to genomic change or cell death. Organisms have developed several pathways and …
lead to genomic change or cell death. Organisms have developed several pathways and …
Gene editing on center stage
Smithies et al.(1985) and Jasin and colleagues (1994) provided proof of concept that
homologous recombination (HR) could be applied to the treatment of human disease and …
homologous recombination (HR) could be applied to the treatment of human disease and …
Strategies for precise gene edits in mammalian cells
KM Fichter, T Setayesh, P Malik - Molecular Therapy-Nucleic Acids, 2023 - cell.com
CRISPR/Cas technologies have the potential to revolutionize genetic medicine. However,
work is still needed to make this technology clinically efficient for gene correction. A barrier …
work is still needed to make this technology clinically efficient for gene correction. A barrier …
[HTML][HTML] Programmable genome editing tools and their regulation for efficient genome engineering
Targeted genome editing has become a powerful genetic tool for studying gene function or
for modifying genomes by correcting defective genes or introducing genes. A variety of …
for modifying genomes by correcting defective genes or introducing genes. A variety of …
Editing the genome without double-stranded DNA breaks
Genome editing methods have commonly relied on the initial introduction of double-
stranded DNA breaks (DSBs), resulting in stochastic insertions, deletions, and translocations …
stranded DNA breaks (DSBs), resulting in stochastic insertions, deletions, and translocations …
Engineering and optimising deaminase fusions for genome editing
Precise editing is essential for biomedical research and gene therapy. Yet, homology-
directed genome modification is limited by the requirements for genomic lesions, homology …
directed genome modification is limited by the requirements for genomic lesions, homology …
Precision genome editing using cytosine and adenine base editors in mammalian cells
Genome editing has transformed the life sciences and has exciting prospects for use in
treating genetic diseases. Our laboratory developed base editing to enable precise and …
treating genetic diseases. Our laboratory developed base editing to enable precise and …
Non-homologous end joining and homology directed DNA repair frequency of double-stranded breaks introduced by genome editing reagents
M Zaboikin, T Zaboikina, C Freter, N Srinivasakumar - PloS one, 2017 - journals.plos.org
Genome editing using transcription-activator like effector nucleases or RNA guided
nucleases allows one to precisely engineer desired changes within a given target …
nucleases allows one to precisely engineer desired changes within a given target …
Prime editing: a new way for genome editing
Precise and efficient use of genome editing tools are hampered by the introduction of DNA
double-strand breaks, donor DNA templates, or homology-directed repair. A recent study …
double-strand breaks, donor DNA templates, or homology-directed repair. A recent study …