Extracellular thiol/disulfide redox environments are highly regulated in healthy individuals.
The major thiol/disulfide redox couple in human plasma is cysteine (Cys) and its disulfide …

The redox potential of the plasma cysteine/cystine couple (EhCySS) is oxidized in
association with risk factors for cardiovascular disease (CVD), including age, smoking, type …

Background—Oxidative stress, a contributing factor to atherosclerosis, causes oxidation of
biological thiols, which can be quantified in terms of the thiol/disulfide redox. The major …

In the cardiovascular system, changes in oxidative balance can affect many aspects of
cellular physiology through redox-signaling. Depending on the magnitude, fluctuations in …

Thiol groups are crucially involved in signaling/homeostasis through oxidation, reduction,
and disulphide exchange. The overall thiol pool is the resultant of several individual pools of …

Background Cysteine (Cys) and its disulfide, cystine (CySS) represent the major
extracellular thiol/disulfide redox control system. The redox potential (Eh) of Cys/CySS is …

Oxidative stress is often defined as an imbalance of pro-oxidants and antioxidants, which
can be quantified in humans as the redox state of plasma GSH/GSSG. Plasma GSH redox in …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Free radical-derived reactive oxygen species (ROS) are constantly generated in most living
tissue and can potentially damage DNA, proteins and lipids.“Oxidative stress” occurs if ROS …

A well-regulated redox state is essential for normal physiological function and cellular
metabolism. In most eukaryotic cells, protein cysteine thiols are most sensitive to fluctuations …