Advanced neuroimaging approaches in amyotrophic lateral sclerosis: refining the clinical diagnosis
J Kassubek, HP Müller - Expert review of neurotherapeutics, 2020 - Taylor & Francis
Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …
The present and the future of neuroimaging in amyotrophic lateral sclerosis
In patients with ALS, conventional MR imaging is frequently noninformative, and its use has
been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive …
been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive …
Multimodal MRI as a diagnostic biomarker for amyotrophic lateral sclerosis
BR Foerster, RC Carlos, BA Dwamena… - Annals of clinical …, 2014 - Wiley Online Library
Objective Reliable biomarkers for amyotrophic lateral sclerosis (ALS) are needed, given the
clinical heterogeneity of the disease. Here, we provide proof‐of‐concept for using …
clinical heterogeneity of the disease. Here, we provide proof‐of‐concept for using …
Neuroimaging in amyotrophic lateral sclerosis: current and emerging uses
Introduction: Several neuroimaging techniques have been used to define in vivo markers of
pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence …
pathological alterations underlying amyotrophic lateral sclerosis (ALS). Growing evidence …
[HTML][HTML] Neuroimaging endpoints in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative, clinically
heterogeneous syndrome pathologically overlapping with frontotemporal dementia. To date …
heterogeneous syndrome pathologically overlapping with frontotemporal dementia. To date …
Pathological insights derived from neuroimaging in amyotrophic lateral sclerosis: emerging clinical applications
The neural signature of cortical and subcortical dysfunction in ALS has been well defined at
the population level. Objective metrics of focal primary motor dysfunction are increasingly …
the population level. Objective metrics of focal primary motor dysfunction are increasingly …
[HTML][HTML] Development of an automated MRI-based diagnostic protocol for amyotrophic lateral sclerosis using disease-specific pathognomonic features: a quantitative …
C Schuster, O Hardiman, P Bede - PLoS One, 2016 - journals.plos.org
Background Despite significant advances in quantitative neuroimaging, the diagnosis of
ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis …
ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis …
Advances in the application of MRI to amyotrophic lateral sclerosis
Importance of the field: With the emergence of therapeutic candidates for the incurable and
rapidly progressive neurodegenerative condition of amyotrophic lateral sclerosis (ALS), it …
rapidly progressive neurodegenerative condition of amyotrophic lateral sclerosis (ALS), it …
[HTML][HTML] Developing a neuroimaging biomarker for amyotrophic lateral sclerosis: multi-center data sharing and the road to a “Global Cohort”
Neuroimaging in Amyotrophic Lateral Sclerosis (ALS) has steadily evolved from an
academic exercise to a powerful clinical tool for detecting and following pathological …
academic exercise to a powerful clinical tool for detecting and following pathological …
[HTML][HTML] What does imaging reveal about the pathology of amyotrophic lateral sclerosis?
MR Turner, E Verstraete - Current neurology and neuroscience reports, 2015 - Springer
Amyotrophic lateral sclerosis (ALS) is now recognised to be a heterogeneous
neurodegenerative syndrome of the motor system and its frontotemporal cortical …
neurodegenerative syndrome of the motor system and its frontotemporal cortical …