The objective of this study was to elucidate the pharmacokinetics and metabolite formation
of newly developed non‐selective AC hE/BC hE 7‐MEOTA‐donepezil‐like inhibitors for …

A simple, rapid and sensitive method based on liquid chromatography–tandem mass
spectrometry (LC–MS/MS) has been developed and validated for the quantitative …

Abstract Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most
preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP …

A series of novel donepezil derivatives was designed, synthesized and evaluated as
multifunctional acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer's …

In a continuing effort to develop multitargeted compounds as potential treatment agents
against Alzheimer's disease (AD), a series of donepezil-like compounds were designed …

Donepezil hydrochloride ((±)-2-[(1-benzylpiperidin-4-yl) methyl]-5, 6-dimethoxy-indan-1-one
monohydrochloride: E2020: donepezil) is a potent and selective acetylcholinesterase …

The synthesis, biological assessment and molecular modeling of new pyridonepezils1–8,
able to inhibit human acetylcholinesterase (hAChE) and human butyrylcholinesterase …

A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment
of Alzheimer's disease, were designed and synthesised based upon previously unexplored …

With the aim of reducing side effects of acetylcholinesterase inhibitors (AChEIs) during
symptomatic treatment of Alzheimer's disease, we report herein a new class of donepezil …

A series of 22 donepezil analogues were synthesized through alkylation/benzylation and
compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be …