Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy
Aim: Due to the complex nature of Alzheimer's disease, there is a renewed search for
multitarget directed drugs. Results: This paper describes the synthesis and in vitro biological …
multitarget directed drugs. Results: This paper describes the synthesis and in vitro biological …
Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42 Aggregation Inhibitors for Alzheimer's …
Y Dgachi, L Ismaili, D Knez, M Benchekroun… - …, 2016 - Wiley Online Library
Given the complex nature of Alzheimer′ s disease (AD), compounds that are able to
simultaneously address two or more AD‐associated targets show greater promise for …
simultaneously address two or more AD‐associated targets show greater promise for …
Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer's …
Y Dgachi, OM Bautista-Aguilera, M Benchekroun… - Molecules, 2016 - mdpi.com
We report herein the straightforward two-step synthesis and biological assessment of novel
racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors …
racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors …
Synthesis, Biological Evaluation, and Molecular Docking of 8‐imino‐2‐oxo‐2H,8H‐pyrano[2,3‐f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs …
Alzheimer's disease onset and progression are associated with the dysregulation of multiple
and complex physiological processes, and a successful therapeutic approach should …
and complex physiological processes, and a successful therapeutic approach should …
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9, 10, 11, 12-tetrahydro-7H-benzo [7, 8] chromeno [2, 3-b] quinolin-8-amines as potential …
The synthesis, pharmacological analysis and molecular modeling of the readily available
racemic tacrine analogs 21–30, bearing the 7-aryl-9, 10, 11, 12-tetrahydro-7H-benzo [7, 8] …
racemic tacrine analogs 21–30, bearing the 7-aryl-9, 10, 11, 12-tetrahydro-7H-benzo [7, 8] …
Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8, 9, 10, 12 …
MJ Oset-Gasque, MP González, J Pérez-Peña… - European Journal of …, 2014 - Elsevier
The pharmacological analysis of racemic chromenotacrines (CT) 1–7, bearing the 11-amino-
12-aryl-8, 9, 10, 12-tetrahydro-7H-chromeno [2, 3-b] quinolin-3-ol ring skeleton, in a series of …
12-aryl-8, 9, 10, 12-tetrahydro-7H-chromeno [2, 3-b] quinolin-3-ol ring skeleton, in a series of …
Design, synthesis and biological evaluation of 2-Phenyl-4H-chromen-4-one derivatives as polyfunctional compounds against Alzheimer's disease
M Singh, M Kaur, B Vyas, O Silakari - Medicinal Chemistry Research, 2018 - Springer
Polyfunctional compounds comprise a novel class of therapeutic agents for the treatment of
multi-factorial diseases. A series of 2-Phenyl-4 H-chromen-4-one and its derivatives (5a–n) …
multi-factorial diseases. A series of 2-Phenyl-4 H-chromen-4-one and its derivatives (5a–n) …
[PDF][PDF] Microwave assisted a practical synthesis of 4-imino-3-phenyl-3, 4-dihydro-1H-chromeno [2, 3-d] pyrimidine-2 (5H)-thione derivatives and exploration of their …
A Bouattour, M Fakhfakh, S Abid, L Paquin… - Arkivoc, 2017 - arkat-usa.org
The interest for 4H-chromenes and their derivatives increased since the two last decades
because this class of compounds are components of many naturally occurring products and …
because this class of compounds are components of many naturally occurring products and …
Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease …
GF Makhaeva, NP Boltneva, SV Lushchekina… - Bioorganic & Medicinal …, 2018 - Elsevier
We investigated the biological activity of a series of substituted chromeno [3, 2-c] pyridines,
including compounds previously synthesized by our group and novel compounds whose …
including compounds previously synthesized by our group and novel compounds whose …
New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer's Disease, with Cholinergic, Antioxidant, and β-Amyloid …
MI Fernández-Bachiller, C Pérez… - Journal of medicinal …, 2012 - ACS Publications
By using fragments endowed with interesting and complementary properties for the
treatment of Alzheimer's disease (AD), a new family of tacrine–4-oxo-4 H-chromene hybrids …
treatment of Alzheimer's disease (AD), a new family of tacrine–4-oxo-4 H-chromene hybrids …