Confidential: For Review Only Page 1 Confidential: For Review Only Evaluating the effects of
Risk Mitigation Guidance opioid and stimulant dispensations on mortality and acute care visits …

Objective To determine the effect of opioid and stimulant Risk Mitigation Guidance (RMG)
dispensations on mortality and acute care visits during the dual public health emergencies …

Canada is experiencing an ongoing opioid-related public health crisis, including persistently
rising opioid (eg, poisoning) mortality. Previous research has documented marked …

Introduction There is an epidemic of opioid use related to adverse events and deaths in the
USA. The rates of chronic pain, mental illness and substance use disorder are higher at the …

We review evidence of determinants contributing to increased opioid-related mortality in the
United States and Canada between 1990 and 2013. We identified 17 determinants of opioid …

Importance In 2021, more than 80 000 US residents died from an opioid overdose. Public
health intervention initiatives, such as the Helping to End Addiction Long-term (HEALing) …

Objective To assess changes in mortality rates in extended-release and long-acting (ER/LA)
opioid analgesics after the implementation of the Risk Evaluation and Mitigation Strategy …

Objectives: High-risk opioid-prescribing practices contribute to a national epidemic of opioid-
related morbidity and mortality. The objective of this study was to determine whether the …

Introduction In March 2016, the Centers for Disease Control and Prevention issued opioid
prescribing guidelines for chronic noncancer pain. In response, in April 2016, the North …

In response to the proliferation and abuse of opioids in the United States, the US Food and
Drug Administration (FDA) recently required manufacturers of extended-release and long …