Ischemic stroke is a devastating disease with a complex pathophysiology. Animal modeling
of ischemic stroke serves as an indispensable tool first to investigate mechanisms of …

Rodent models of focal cerebral ischemia are essential tools in experimental stroke
research. They have added tremendously to our understanding of injury mechanisms in …

This review outlines the most frequently used rodent stroke models and discusses their
strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is …

Translation of acute ischemic stroke research to the clinical setting remains limited over the
last few decades with only one drug, recombinant tissue-type plasminogen activator …

Ischemic stroke triggers a complex and highly interconnected cascade of cellular and
molecular events. Early events induced following ischemic injury, including excitotoxicity …

Stroke is a major cause of both death and disability. However, there are no pharmacological
treatments used in most countries other than recombinant tissue plasminogen activator, a …

Translation from basic science bench research in ischemic stroke to bedside treatment of
patients suffering ischemic stroke remains a difficult challenge. Despite literally hundreds of …

Substantial efforts are being made to develop drugs which will protect the brain from the
neurodegeneration that follows an acute ischaemic stroke. However, while there are already …

Despite the impressive efficacies demonstrated in preclinical research, hundreds of
potentially neuroprotective drugs have failed to provide effective neuroprotection for …

This review describes the most commonly used rodent models and outcome measures in
preclinical stroke research and discusses their strengths and limitations. Most models …