Cell and nucleus refractive‐index mapping by interferometric phase microscopy and rapid confocal fluorescence microscopy

S Cohen‐Maslaton, I Barnea, A Taieb… - Journal of …, 2020 - Wiley Online Library
We present a multimodal technique for measuring the integral refractive index and the
thickness of biological cells and their organelles by integrating interferometric phase …

Integral refractive index imaging of flowing cell nuclei using quantitative phase microscopy combined with fluorescence microscopy

G Dardikman, YN Nygate, I Barnea… - Biomedical optics …, 2018 - opg.optica.org
We suggest a new multimodal imaging technique for quantitatively measuring the integral
(thickness-average) refractive index of the nuclei of live biological cells in suspension. For …

Generalized cell morphological parameters based on interferometric phase microscopy and their application to cell life cycle characterization

P Girshovitz, NT Shaked - Biomedical optics express, 2012 - opg.optica.org
We present analysis tools which are formulated using wide-field interferometric phase
microscopy measurements, and show their ability to uniquely quantify the life cycle of live …

Real-time simultaneous refractive index and thickness mapping of sub-cellular biology at the diffraction limit

A Burguete-Lopez, M Makarenko, M Bonifazi… - Communications …, 2024 - nature.com
Mapping the cellular refractive index (RI) is a central task for research involving the
composition of microorganisms and the development of models providing automated …

Live cell refractometry using Hilbert phase microscopy and confocal reflectance microscopy

N Lue, W Choi, G Popescu, Z Yaqoob… - The Journal of …, 2009 - ACS Publications
Quantitative chemical analysis has served as a useful tool for understanding cellular
metabolisms in biology. Among many physical properties used in chemical analysis …

[HTML][HTML] Self-reference line-dispersion interferometric microscopy

P Hosseini, N Lue, Z Yaqoob, RR Dasari… - Applied Physics …, 2017 - pubs.aip.org
We have developed a line-scanning interferometric microscope capable of measuring the
quantitative phase over a wide continuous spectrum. The sample is illuminated with a …

Quantitative refractive index distribution of single cell by combining phase-shifting interferometry and AFM imaging

Q Zhang, L Zhong, P Tang, Y Yuan, S Liu, J Tian… - Scientific reports, 2017 - nature.com
Cell refractive index, an intrinsic optical parameter, is closely correlated with the intracellular
mass and concentration. By combining optical phase-shifting interferometry (PSI) and atomic …

Full-field optical coherence microscopy for identifying live cancer cells by quantitative measurement of refractive index distribution

WJ Choi, DI Jeon, SG Ahn, JH Yoon, S Kim, BH Lee - Optics express, 2010 - opg.optica.org
The feasibility of identifying cancer cells by measuring the refractive index (RI) distribution
across a single live cell with ultrahigh resolution full-field optical coherence microscopy (FF …

Group refractive index reconstruction with broadband interferometric confocal microscopy

DL Marks, SC Schlachter, AM Zysk, SA Boppart - JOSA A, 2008 - opg.optica.org
We propose a novel method of measuring the group refractive index of biological tissues at
the micrometer scale. The technique utilizes a broadband confocal microscope embedded …

Single-shot dual-wavelength interferometric microscopy

P Hosseini, D Jin, Z Yaqoob, PTC So - Methods, 2018 - Elsevier
Interferometric microscopy (IM) can provide complex field information of the biological
samples with high spatial and temporal resolution with virtually no photodamage. Measuring …