[HTML][HTML] Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development

G Andrei, R Snoeck - Trends in Pharmacological Sciences, 2023 - cell.com
Since May 2022, mpox virus (MPXV) has attracted considerable attention due to a multi-
country outbreak. Marked differences in epidemiology, transmission, and pathology between …

Genomic analyses of recently emerging clades of mpox virus reveal gene deletion and single nucleotide polymorphisms that correlate with altered virulence and …

A Kumar, P Jhanwar, A Gulati, U Tatu - bioRxiv, 2024 - biorxiv.org
Mpox virus (MPXV) has consistently caused human infections since the first reported case in
1970, with the initial outbreaks primarily attributed to sporadic zoonotic transmissions. In …

Genomic epidemiology uncovers the timing and origin of the emergence of mpox in humans

E Parker, I Omah, P Varilly, A Magee, AO Ayinla… - medRxiv, 2024 - medrxiv.org
Five years before the 2022 global mpox outbreak Nigeria reported its first cases in nearly 40
years, with the ongoing epidemic since driven by sustained human-to-human transmission …

[HTML][HTML] Emergence, phylogeography, and adaptive evolution of mpox virus

H Guan, I Gul, C Xiao, S Ma, Y Liang, D Yu… - New Microbes and New …, 2023 - Elsevier
Mpox (Monkeypox) is a zoonotic disease caused by mpox virus (MPXV). A multi-country
MPXV outbreak in non-endemic demographics was identified in May 2022. A systematic …

[HTML][HTML] Emergence of mpox in the post-smallpox era-a narrative review on mpox epidemiology

C Van Dijck, NA Hoff, P Mbala-Kingebeni, N Low… - Clinical Microbiology …, 2023 - Elsevier
Background The 2022 mpox outbreak drew global attention to this neglected pathogen.
While most of the world was taken by surprise, some countries have seen this pathogen …

[HTML][HTML] Mpox, Caused by the MPXV of the Clade IIb lineage, goes global

L Gao, Q Shi, X Dong, M Wang, Z Liu, Z Li - Tropical Medicine and …, 2023 - mdpi.com
Mpox is a great public health concern worldwide currently; thus, a global primary
epidemiological analysis of mpox and a phylogenetic analysis of currently circulating MPXV …

[HTML][HTML] Mpox virus: its molecular evolution and potential impact on viral epidemiology

X Yu, H Shi, G Cheng - Viruses, 2023 - mdpi.com
Mpox (previously known as monkeypox) is an infectious viral illness caused by the mpox
virus (MPXV), an orthopoxvirus that belongs to the family Poxviridae. The symptoms of mpox …

Clade I Mpox virus genomic diversity in the Democratic Republic of the Congo, 2018-2024: Predominance of Zoonotic Transmission

E Kinganda-Lusamaki, A Amuri-Aziza, N Fernandez… - medRxiv, 2024 - medrxiv.org
Background: Recent reports raise concerns on the changing epidemiology of mpox in the
Democratic Republic of the Congo (DRC), with increasing case counts, sexual contact …

Pathogenesis of the circulating mpox virus and its adaptation to humans

A Alcamí - Proceedings of the National Academy of …, 2023 - National Acad Sciences
The recent mpox (monkeypox) outbreak has caused> 86,000 infections and 96 deaths
(https://ourworldindata. org/monkeypox) and was declared a global health emergency by the …

Genomic recombination of rapidly evolving mpox Ib strains compounds the challenges of the 2024 outbreak

TY Yeh, PJ Feehley, MC Feehley, CF Chen, TY Tsai… - medRxiv, 2024 - medrxiv.org
The World Health Organization recently declared the 2024 mpox virus (MPXV Ib) outbreak a
public health emergency of international concern. We report that in 2023-2024, MPXV clade …