Lipid redistribution in the highly curved footprint of Piezo1
We investigate the effects on the distribution of lipids in the plasma membrane that are
caused by the insertion of a protein, Piezo1, that significantly distorts the membrane toward …
caused by the insertion of a protein, Piezo1, that significantly distorts the membrane toward …
[HTML][HTML] Modeling of full-length Piezo1 suggests importance of the proximal N-terminus for dome structure
Piezo1 forms a mechanically activated calcium-permeable nonselective cation channel that
is functionally important in many cell types. Structural data exist for C-terminal regions, but …
is functionally important in many cell types. Structural data exist for C-terminal regions, but …
Piezo1 induces local curvature in a mammalian membrane and forms specific protein-lipid interactions
Touch, hearing, and blood pressure control require mechanically-gated ion channels that
convert mechanical stimuli into electrical currents. Piezo1 and Piezo2 were recently …
convert mechanical stimuli into electrical currents. Piezo1 and Piezo2 were recently …
Amphipathic molecules modulate PIEZO1 activity
CD Cox, PA Gottlieb - Biochemical Society Transactions, 2019 - portlandpress.com
PIEZO proteins are large eukaryotic mechanically-gated channels that function as
homotrimers. The basic PIEZO1 structure has been elucidated by CryoEM and it assembles …
homotrimers. The basic PIEZO1 structure has been elucidated by CryoEM and it assembles …
Computational reconstruction of the complete Piezo1 structure reveals a unique footprint and specific lipid interactions
J Chong, D De Vecchis, AJ Hyman, OV Povstyan, J Shi… - BioRxiv, 2019 - biorxiv.org
Piezo1 is a critical mechanical sensor in many cells. It is activated by mechanical force thus
allowing cells to sense the physical environment and respond to stress. Structural data have …
allowing cells to sense the physical environment and respond to stress. Structural data have …
Molecular principles of Piezo1 activation by increased membrane tension
D De Vecchis, DJ Beech, AC Kalli - bioRxiv, 2019 - biorxiv.org
SUMMARY PARAGRAPH Piezo1 is a mechanosensitive channel involved in many cellular
functions and responsible for sensing shear-stress and pressure forces in cells1–3. Piezo1 …
functions and responsible for sensing shear-stress and pressure forces in cells1–3. Piezo1 …
[HTML][HTML] Molecular dynamics simulations of Piezo1 channel opening by increases in membrane tension
D De Vecchis, DJ Beech, AC Kalli - Biophysical journal, 2021 - cell.com
Piezo1 is a mechanosensitive channel involved in many cellular functions and responsible
for sensing shear stress and pressure forces in cells. Piezo1 has a unique trilobed topology …
for sensing shear stress and pressure forces in cells. Piezo1 has a unique trilobed topology …
Cholesterol-Dependent Piezo1 Clusters are Essential for Efficient Cellular Mechanotransduction
The human mechanosensitive ion channel PIEZO1 is gated by membrane tension and
regulates essential biological processes such as vascular development and erythrocyte …
regulates essential biological processes such as vascular development and erythrocyte …
Human Piezo1 membrane localization and gating kinetics are modulated by cholesetrol levels
The human mechanosensitive ion channel Piezo1 gates in response to membrane tension
and regulates essential biological processes such as vascular development and erythrocyte …
and regulates essential biological processes such as vascular development and erythrocyte …
Piezo1 forms specific, functionally important interactions with phosphoinositides and cholesterol
Touch, hearing, and blood pressure regulation require mechanically gated ion channels that
convert mechanical stimuli into electrical currents. One such channel is Piezo1, which plays …
convert mechanical stimuli into electrical currents. One such channel is Piezo1, which plays …