Despite the many advances in critical care medicine, sepsis continues to be a major health
problem, with a high morbidity and mortality [1]. Sepsis is best characterized as a systemic …

Oxygen therapy is currently used as a supportive treatment in septic patients to improve
tissue oxygenation. However, oxygen can exert deleterious effects on the inflammatory …

Supplemental oxygen is a supportive treatment in patients with sepsis to balance tissue
oxygen delivery and demand in the tissues. However, hyperoxia may induce some …

BACKGROUND: The 100% oxygen inhalation has been demonstrated to have a protective
effect on mice with zymosan-induced generalized inflammation. However, the underlying …

The prognosis and care of critically ill ICU patients has improved over recent years, but the
development of multiple organ failure (MOF) continues to cause significant morbidity and …

Sepsis/multiple organ dysfunction syndrome (MODS) is a major cause of high mortality in
the intensive care unit. We have recently reported that 100% oxygen treatment is beneficial …

Objective: Inhalation of oxygen improves the hemodynamic status and attenuates the
inflammatory response after intestinal ischemia-reperfusion (IR). Yet, the use of hyperoxia is …

Human sepsis is thought to be systemic inflammatory response syndrome (SIRS) that is
activated by invasive infection. The multiple organ dysfunction syndrome (MODS) is the …

Background. Mitochondrial oxidative stress has a role in sepsis-induced organ dysfunction.
The endogenous mechanisms to initiate protective pathways are controlled by peroxisome …

Despite modern practices in critical care medicine, sepsis or systemic inflammatory
response syndrome remains a leading cause of morbidity and mortality in the intensive care …