Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

Background Genome-wide association studies have established clusterin (CLU) as a
genetic modifier for late-onset Alzheimer's disease (AD). Both protective and risk alleles …

The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's
disease (AD) risk. The mechanism underlying this association is unclear. Here, we report …

Clusterin, also known as apolipoprotein J, is a versatile chaperone molecule which contains
several amphipathic and coiled-coil α-helices, typical characteristics of small heat shock …

Context Variants in the clusterin gene are associated with the risk of Alzheimer disease (AD)
and clusterin levels have been found to be increased in brain and cerebrospinal fluid of …

Context Blood-based analytes may be indicators of pathological processes in Alzheimer
disease (AD). Objective To identify plasma proteins associated with AD pathology using a …

Clusterin, also known as apoJ, is a lipoprotein abundantly expressed within the CNS. It
regulates Aβ fibril formation and toxicity and facilitates amyloid‐β (Aβ) transport across the …

Sporadic or late-onset Alzheimer's disease (AD) is expected to affect 50% of individuals
reaching 85 years of age. The most significant genetic risk factor for late-onset AD is the e4 …

Genetic variation in clusterin gene, also known as apolipoprotein J, has been associated
with Alzheimer's disease (AD) through replicated genome-wide studies, and plasma …

In recent genome-wide association studies, the extracellular chaperone protein, clusterin,
has been identified as a newly-discovered risk factor in Alzheimer's disease. We have …