Members of the Shank protein family are master scaffolds of the postsynaptic architecture
and mutations within the SHANK genes are causally associated with autism spectrum …

The postsynaptic scaffolding protein SH3 and multiple ankyrin repeat domains 3 (SHANK3)
is critical for the development and function of glutamatergic synapses. Disruption of the …

We previously reported a new line of Shank3 mutant mice which led to a complete loss of
Shank3 by deleting exons 4− 22 (Δe4− 22) globally. Δe4− 22 mice display robust ASD-like …

Background Deletion or mutations of SHANK3 lead to Phelan–McDermid syndrome and
monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous …

Shank3 is a multi‐domain, synaptic scaffolding protein that organizes proteins in the
postsynaptic density of excitatory synapses. Clinical studies suggest that∼ 0.5% of autism …

Shank2 is an excitatory postsynaptic scaffolding protein implicated in synaptic regulation
and psychiatric disorders including autism spectrum disorders. Conventional Shank2-mutant …

Mutations within the Shank3 gene, which encodes a key postsynaptic density (PSD) protein
at glutamatergic synapses, contribute to the genetic etiology of defined autism spectrum …

Shank family proteins (Shank1, Shank2, and Shank3) are synaptic scaffolding proteins that
organize an extensive protein complex at the postsynaptic density (PSD) of excitatory …

Mutations in SHANK genes play an undisputed role in neuropsychiatric disorders. Until now,
research has focused on the postsynaptic function of SHANKs, and prominent postsynaptic …

Background Considerable clinical heterogeneity has been well documented amongst
individuals with autism spectrum disorders (ASD). However, little is known about the …