Pyroptosis is a necrotic form of regulated cell death. Gasdermines (GSDMs) are a family of
intracellular proteins that execute pyroptosis. While GSDMs are expressed as inactive forms …

Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …

Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis,
which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still …

Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections
play an extremely important role in a variety of diseases. This paper describes the types of …

Over the past three decades, an intricate interaction between immune activation, release of
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …

Alcohol affects many organs, including the immune system, with even moderate amounts of
alcohol influencing immune responses. Although alcohol can alter the actions of all cell …

Inflammasomes are innate immune mechanisms that promote inflammation by activating the
protease caspase‐1. Active caspase‐1 induces pyroptosis, a necrotic form of regulated cell …

IL-1α serves as a pro-inflammatory cytokine. Although pro-IL-1α has cytokine activity,
proteolytic maturation increases its potency and release from cells. IL-1α maturation occurs …

The skin is an organ harboring several types of immune cells that participate in innate and
adaptive immune responses. The immune system of the skin comprises both skin cells and …

Lycopene (Lyc) as a natural antioxidant has attracted widespread attention. Di (2-ethylhexyl)
phthalate (DEHP) can cause serious spleen injury in animals via the environment and food …