Nucleic acid sensing is a critical mechanism by which the immune system monitors for
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …

The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …

Apoptosis is a genetically regulated cell suicide programme mediated by activation of the
effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and …

The skin is an organ harboring several types of immune cells that participate in innate and
adaptive immune responses. The immune system of the skin comprises both skin cells and …

Abstract Hydrogen peroxide (H2O2) has a major function in host-microbial interactions.
Although most studies have focused on the endogenous H2O2 produced by immune cells to …

Inflammasomes are cytosolic polyprotein complexes formed in response to various external
and internal stimuli, including viral and bacterial antigens. The main product of the …

Inflammasomes have emerged as critical innate sensors of host immune that defense
against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in …

Silica is an essential substrate of various materials, and inhaling silica induces pulmonary
diseases potentially associated with macrophage pyroptosis. Utilizing silica of micro-and …

Inflammasomes are cytosolic multiprotein complexes that orchestrate inflammation in
response to pathogens and endogenous danger signals. Herein, we determined whether …

ATP acts as a canonical activator to induce NLRP3 (NOD-like receptor family, pyrin domain
containing 3) inflammasome activation in macrophages, leading to caspase-1/gasdermin D …