How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions
J Chen, JC Deng, DR Goldstein - Trends in molecular medicine, 2022 - cell.com
Aging leads to a gradual dysregulation of immune functions, one consequence of which is
reduced vaccine efficacy. In this review, we discuss several key contributing factors to the …
reduced vaccine efficacy. In this review, we discuss several key contributing factors to the …
[HTML][HTML] Importance and value of adjuvanted influenza vaccine in the care of older adults from a European perspective–A systematic review of recently published …
BC Gärtner, T Weinke, K Wahle, A Kwetkat, D Beier… - Vaccine, 2022 - Elsevier
Background There is an urgent need for improved influenza vaccines especially for older
adults due to the presence of immunosenescence. It is therefore highly relevant to compare …
adults due to the presence of immunosenescence. It is therefore highly relevant to compare …
[HTML][HTML] Safety and immunogenicity of a high-dose quadrivalent influenza vaccine administered concomitantly with a third dose of the mRNA-1273 SARS-CoV-2 …
R Izikson, D Brune, JS Bolduc, P Bourron… - The Lancet …, 2022 - thelancet.com
Background Concomitant seasonal influenza vaccination with a COVID-19 vaccine booster
could help to minimise potential disruption to the seasonal influenza vaccination campaign …
could help to minimise potential disruption to the seasonal influenza vaccination campaign …
A pragmatic randomized feasibility trial of influenza vaccines
Background The relative vaccine effectiveness (rVE) of high-dose quadrivalent influenza
vaccines (QIV-HD) versus standard-dose quadrivalent influenza vaccines (QIV-SD) against …
vaccines (QIV-HD) versus standard-dose quadrivalent influenza vaccines (QIV-SD) against …
[HTML][HTML] Immunosenescence and altered vaccine efficiency in older subjects: A myth difficult to change
Organismal ageing is associated with many physiological changes, including differences in
the immune system of most animals. These differences are often considered to be a key …
the immune system of most animals. These differences are often considered to be a key …
[HTML][HTML] Comparative effectiveness of adjuvanted versus high-dose seasonal influenza vaccines for older adults: a systematic review and meta-analysis
A Domnich, C de Waure - International Journal of Infectious Diseases, 2022 - Elsevier
Objectives MF59-adjuvanted standard-dose and nonadjuvanted high-dose seasonal
influenza vaccines have been developed to protect the elderly at high risk of severe …
influenza vaccines have been developed to protect the elderly at high risk of severe …
[HTML][HTML] Vaccination against community-acquired pneumonia in spanish adults: practical recommendations by the NeumoExperts prevention group
E Redondo, I Rivero-Calle, E Mascarós, D Ocaña… - Antibiotics, 2023 - mdpi.com
In the adult population, community-acquired pneumonia (CAP) is a serious disease that is
responsible for high morbidity and mortality rates, being frequently associated with multidrug …
responsible for high morbidity and mortality rates, being frequently associated with multidrug …
Immunogenicity and safety of a quadrivalent high-dose inactivated influenza vaccine compared with a standard-dose quadrivalent influenza vaccine in healthy people …
S Pepin, JF Nicolas, H Szymanski… - Human Vaccines & …, 2021 - Taylor & Francis
ABSTRACT A quadrivalent high-dose inactivated influenza vaccine (IIV4-HD) is licensed for
adults≥ 65 y of age based on immunogenicity and efficacy studies. However, IIV4-HD has …
adults≥ 65 y of age based on immunogenicity and efficacy studies. However, IIV4-HD has …
[HTML][HTML] High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update
JKH Lee, GKL Lam, JK Yin, MM Loiacono, SI Samson - Vaccine: X, 2023 - Elsevier
This updated systematic review and meta-analysis of randomized and observational studies
published up to April 2023 assessed the relative performance of high-dose inactivated …
published up to April 2023 assessed the relative performance of high-dose inactivated …
[HTML][HTML] Seasonal influenza vaccine effectiveness in persons aged 15–64 years: A systematic review and meta-analysis
JP Martins, M Santos, A Martins, M Felgueiras… - Vaccines, 2023 - mdpi.com
Influenza is a respiratory disease caused by the influenza virus, which is highly
transmissible in humans. This paper presents a systematic review and meta-analysis of …
transmissible in humans. This paper presents a systematic review and meta-analysis of …