Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …

Autograft replaced by a nerve guidance conduit (NGC) is challenging in peripheral nerve
injury because current NGC is still limited by precise conductivity and excellent …

Uncovering differences between crystalline and amorphous states in molecular solids would
both promote the understanding of their structure–property relationships, as well as inform …

This work describes the use of fused deposition modelling (FDM) to prepare antiplatelet
thermoplastic polyurethane (TPU)-based tubular grafts. FDM 3D-printing technology is …

Enteric polymers are widely used in amorphous solid dispersion (ASD) formulations. The
aim of the current study was to explore ASD failure mechanisms across a wide range of pH …

Solid dispersions have achieved significant interest as an effective means of enhancing the
dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid …

Weakly acid polymers with pH-responsive solubility are being used with increasing
frequency in amorphous solid dispersion (ASD) formulations of drugs with low aqueous …

The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

In recent years, poorly water-soluble drug candidates in the drug development pipeline have
been a challenging issue for the pharmaceutical industry. Many delivery systems, such as …