[HTML][HTML] Recent advances in amorphous solid dispersions: preformulation, formulation strategies, technological advancements and characterization
Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
Three potential elements of developing nerve guidance conduit for peripheral nerve regeneration
C Zhang, J Gong, J Zhang, Z Zhu… - Advanced Functional …, 2023 - Wiley Online Library
Autograft replaced by a nerve guidance conduit (NGC) is challenging in peripheral nerve
injury because current NGC is still limited by precise conductivity and excellent …
injury because current NGC is still limited by precise conductivity and excellent …
Leveraging crystalline and amorphous states of a metal‐organic complex for transformation of the photosalient effect and positive‐negative photochromism
YJ Ma, G Xiao, X Fang, T Chen… - Angewandte Chemie …, 2023 - Wiley Online Library
Uncovering differences between crystalline and amorphous states in molecular solids would
both promote the understanding of their structure–property relationships, as well as inform …
both promote the understanding of their structure–property relationships, as well as inform …
[HTML][HTML] TPU-based antiplatelet cardiovascular prostheses prepared using fused deposition modelling
J Domínguez-Robles, E Utomo, VA Cornelius… - Materials & Design, 2022 - Elsevier
This work describes the use of fused deposition modelling (FDM) to prepare antiplatelet
thermoplastic polyurethane (TPU)-based tubular grafts. FDM 3D-printing technology is …
thermoplastic polyurethane (TPU)-based tubular grafts. FDM 3D-printing technology is …
Impact of gastric pH variations on the release of amorphous solid dispersion formulations containing a weakly basic drug and enteric polymers
Enteric polymers are widely used in amorphous solid dispersion (ASD) formulations. The
aim of the current study was to explore ASD failure mechanisms across a wide range of pH …
aim of the current study was to explore ASD failure mechanisms across a wide range of pH …
Current trends on solid dispersions: past, present, and future
R Malkawi, WI Malkawi, Y Al-Mahmoud… - Advances in …, 2022 - Wiley Online Library
Solid dispersions have achieved significant interest as an effective means of enhancing the
dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid …
dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid …
Fed-and fasted-state performance of pretomanid amorphous solid dispersions formulated with an enteric polymer
HT Nguyen, T Van Duong, S Jaw-Tsai… - Molecular …, 2023 - ACS Publications
Weakly acid polymers with pH-responsive solubility are being used with increasing
frequency in amorphous solid dispersion (ASD) formulations of drugs with low aqueous …
frequency in amorphous solid dispersion (ASD) formulations of drugs with low aqueous …
Amorphous solid dispersions: Utilization and challenges in preclinical drug development within AstraZeneca
AB Anane-Adjei, E Jacobs, SC Nash, S Askin… - International Journal of …, 2022 - Elsevier
The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …
much of the early drug development portfolio and poses a major challenge in …
[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers
J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …
The antisolvent coprecipitation method for enhanced bioavailability of poorly water-soluble drugs
J Zhang, M Liu, Z Zeng - International Journal of Pharmaceutics, 2022 - Elsevier
In recent years, poorly water-soluble drug candidates in the drug development pipeline have
been a challenging issue for the pharmaceutical industry. Many delivery systems, such as …
been a challenging issue for the pharmaceutical industry. Many delivery systems, such as …