Drug–drug co-amorphous systems: An emerging formulation strategy for poorly water-soluble drugs
H Wang, P Zhao, R Ma, J Jia, Q Fu - Drug Discovery Today, 2024 - Elsevier
Overcoming the poor water solubility of small-molecule drugs is a major challenge in the
development of clinical pharmaceuticals. Amorphization of crystalline drugs is a highly …
development of clinical pharmaceuticals. Amorphization of crystalline drugs is a highly …
[HTML][HTML] Combining machine learning and molecular simulations to predict the stability of amorphous drugs
T Barnard, GC Sosso - The Journal of Chemical Physics, 2023 - pubs.aip.org
Amorphous drugs represent an intriguing option to bypass the low solubility of many
crystalline formulations of pharmaceuticals. The physical stability of the amorphous phase …
crystalline formulations of pharmaceuticals. The physical stability of the amorphous phase …
[HTML][HTML] Influence Mechanism of Drug–Polymer Compatibility on Humidity Stability of Crystalline Solid Dispersion
C Hu, Q Yan, Y Zhang, H Yan - Pharmaceuticals, 2023 - mdpi.com
This study investigates the influence of humidity on the dissolution behavior and
microstructure of drugs in crystalline solid dispersions (CSDs). Using Bifonazole (BFZ) as a …
microstructure of drugs in crystalline solid dispersions (CSDs). Using Bifonazole (BFZ) as a …
Efficiency of a Lyophilizate for Dry Powder Inhalation System for Drug Delivery of Ghrelin in Monkeys
T Akita, K Miyamoto, C Yamashita - Drug Delivery Letters, 2024 - ingentaconnect.com
Background: A lyophilizate for dry powder inhalation (LDPI) system is unique in that its
formulation, a lyophilized cake, is aerosolized just upon inhalation by convection flow of air …
formulation, a lyophilized cake, is aerosolized just upon inhalation by convection flow of air …
A review on solubility enhancement technique for pharmaceutical drugs
VB Borgaonkar, CM Jain, AR Jaiswal… - GSC Biological and …, 2024 - gsconlinepress.com
Solubility, a critical parameter governing the bioavailability and therapeutic efficacy of
pharmaceutical compounds, often poses a significant challenge in drug development. This …
pharmaceutical compounds, often poses a significant challenge in drug development. This …