A year of terror and a century of reflection: perspectives on the great influenza pandemic of 1918–1919
ME Nickol, J Kindrachuk - BMC infectious diseases, 2019 - Springer
Background In the spring of 1918, the “War to End All Wars”, which would ultimately claim
more than 37 million lives, had entered into its final year and would change the global …
more than 37 million lives, had entered into its final year and would change the global …
Factors which contribute to the immunogenicity of non-replicating adenoviral vectored vaccines
L Coughlan - Frontiers in immunology, 2020 - frontiersin.org
Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-
replicating Ad vectors possess several attributes which make them attractive vaccines for …
replicating Ad vectors possess several attributes which make them attractive vaccines for …
[HTML][HTML] Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites
Resident memory B (BRM) cells develop and persist in the lungs of influenza-infected mice
and humans; however, their contribution to recall responses has not been defined. Here, we …
and humans; however, their contribution to recall responses has not been defined. Here, we …
Host factors impact vaccine efficacy: implications for seasonal and universal influenza vaccine programs
Influenza is a global public health problem. Current seasonal influenza vaccines have highly
variable efficacy, and thus attempts to develop broadly protective universal influenza …
variable efficacy, and thus attempts to develop broadly protective universal influenza …
The multifaceted B cell response to influenza virus
JH Lam, N Baumgarth - The journal of immunology, 2019 - journals.aai.org
Protection from yearly recurring, highly acute infections with a pathogen that rapidly and
continuously evades previously induced protective neutralizing Abs, as seen during …
continuously evades previously induced protective neutralizing Abs, as seen during …
VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design
Broadly neutralizing antibodies (bnAbs) are potential therapeutic molecules and valuable
tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody …
tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody …
[HTML][HTML] A Research and Development (R&D) roadmap for influenza vaccines: Looking toward the future
KA Moore, JT Ostrowsky, AM Kraigsley, AJ Mehr… - Vaccine, 2021 - Elsevier
Improved influenza vaccines are urgently needed to reduce the burden of seasonal
influenza and to ensure a rapid and effective public-health response to future influenza …
influenza and to ensure a rapid and effective public-health response to future influenza …
Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model
The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention
as a potent target for universal influenza vaccines,,,–. Although the HA stalk region is …
as a potent target for universal influenza vaccines,,,–. Although the HA stalk region is …
Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo …
E Hershberger, S Sloan, K Narayan, CA Hay… - …, 2019 - thelancet.com
Background VIS410, a broadly neutralizing monoclonal antibody that binds the
hemagglutinin stem of influenza A viruses, was safe and efficacious in a human H1N1 virus …
hemagglutinin stem of influenza A viruses, was safe and efficacious in a human H1N1 virus …
Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination
Novel influenza A virus (IAV) strains elicit recall immune responses to conserved epitopes,
making them favorable antigenic choices for universal influenza virus vaccines. Evaluating …
making them favorable antigenic choices for universal influenza virus vaccines. Evaluating …