The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis

P Liu, Y Wang, G Yang, Q Zhang, L Meng, Y Xin… - Pharmacological …, 2021 - Elsevier
Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …

IL-23 in inflammatory bowel diseases and colon cancer

MF Neurath - Cytokine & growth factor reviews, 2019 - Elsevier
Studies in recent years have identified a pivotal role of the cytokine IL-23 in the
pathogenesis of inflammatory bowel diseases (IBD: Crohn´ s disease, ulcerative colitis) and …

[HTML][HTML] New targets for mucosal healing and therapy in inflammatory bowel diseases

MF Neurath - Mucosal immunology, 2014 - Elsevier
Healing of the inflamed mucosa (mucosal healing) is an emerging new goal for therapy and
predicts clinical remission and resection-free survival in inflammatory bowel diseases …

Resveratrol downregulates miR‐31 to promote T regulatory cells during prevention of TNBS‐induced colitis

HR Alrafas, PB Busbee, M Nagarkatti… - Molecular nutrition & …, 2020 - Wiley Online Library
Scope Colitis, an inflammatory bowel disease, is associated with aberrant regulation of the
colonic mucosal immune system. Resveratrol, a natural plant product, has been found to …

Th9 cells in inflammatory bowel diseases

B Weigmann, MF Neurath - Seminars in immunopathology, 2017 - Springer
Inflammatory bowel diseases are chronic, relapsing, immunologically mediated disorders of
the gastrointestinal tract. Emerging evidence suggests a critical functional role of …

Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein

N Suzuki, N Murata-Kamiya, K Yanagiya, W Suda… - Scientific reports, 2015 - nature.com
Helicobacter pylori cagA-positive strain delivers the CagA oncoprotein into gastric epithelial
cells and at the same time elicits stomach inflammation. To experimentally investigate the …

Colitis-associated neoplasia: molecular basis and clinical translation

S Foersch, MF Neurath - Cellular and molecular life sciences, 2014 - Springer
Crohn's disease and ulcerative colitis are both associated with an increased risk of
inflammation-associated colorectal carcinoma. Colitis-associated cancer (CAC) is one of the …

MicroRNA-338-3p inhibits colorectal carcinoma cell invasion and migration by targeting smoothened

Q Xue, K Sun, HJ Deng, ST Lei… - Japanese journal of …, 2014 - academic.oup.com
Objective To investigate the regulative effect of microRNA-338-3p on colorectal carcinoma
cell invasion and migration. Methods The microRNA-338-3p expression pattern of colorectal …

Colorectal dysplasia in inflammatory bowel disease: a clinicopathologic perspective

MD Rutter, RH Riddell - Clinical Gastroenterology and Hepatology, 2014 - Elsevier
Surveillance for neoplasia in colitis is the most challenging diagnostic colonoscopic
procedure. The detection and treatment of colorectal dysplasia in inflammatory bowel …

Hyaluronic a cid–doxorubicin nanoparticles for targeted treatment of colorectal cancer

DC Pan, V Krishnan, AK Salinas, J Kim… - Bioengineering & …, 2021 - Wiley Online Library
Colorectal cancer, common in both men and women, occurs when tumors form in the linings
of the colon. Common treatments of colorectal cancer include surgery, chemotherapy, and …