The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …

Highlights•Aging is associated with a decline in immune function termed 'immune
senescence'.•Effective influenza vaccines need to be developed for better protection the …

Background Seasonal influenza remains a substantial public health threat despite the
availability of egg-derived and other vaccines. Plant-based manufacturing might address …

Background As compared with a standard-dose vaccine, a high-dose, trivalent, inactivated
influenza vaccine (IIV3-HD) improves antibody responses to influenza among adults 65 …

Background New influenza vaccines eliciting more effective protection are needed,
particularly for the elderly who paid a large and disproportional toll of hospitalization and …

Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …

Immunosenescence is defined as the progressive deterioration of the immune system with
aging. Immunosenescence stifles the generation of protective B and T cell-mediated …

Introduction Older adults are prioritized for influenza vaccination but also have lowered
antibody responses to the vaccine. Higher-doses of influenza antigen may increase immune …

Immune thrombocytopenic purpura (ITP) is an autoimmune condition characterized by low
platelet count with mucocutaneous and other bleedings. Clinical manifestations may range …

People with advanced age have a higher susceptibility to infections and exhibit increased
mortality and morbidity as the ability of the immune system to combat infections decreases …