[HTML][HTML] Nanoparticle vaccines
Nanotechnology increasingly plays a significant role in vaccine development. As vaccine
development orientates toward less immunogenic “minimalist” compositions, formulations …
development orientates toward less immunogenic “minimalist” compositions, formulations …
Antibody response to influenza vaccination in the elderly: a quantitative review
K Goodwin, C Viboud, L Simonsen - Vaccine, 2006 - Elsevier
We performed a quantitative review of 31 vaccine antibody response studies conducted from
1986 to 2002 and compared antibody responses to influenza vaccine in groups of elderly …
1986 to 2002 and compared antibody responses to influenza vaccine in groups of elderly …
New horizons in adjuvants for vaccine development
SG Reed, S Bertholet, RN Coler, M Friede - Trends in immunology, 2009 - cell.com
Over the last decade, there has been a flurry of research on adjuvants for vaccines, and
several novel adjuvants are now in licensed products or in late stage clinical development …
several novel adjuvants are now in licensed products or in late stage clinical development …
The history of MF59® adjuvant: a phoenix that arose from the ashes
DT O'Hagan, GS Ott, GV Nest, R Rappuoli… - Expert review of …, 2013 - Taylor & Francis
The first clinical trial of an MF59®-adjuvanted influenza vaccine (Novartis) was conducted
20 years ago in 1992. The product that emerged (Fluad®, Novartis) was licensed first in Italy …
20 years ago in 1992. The product that emerged (Fluad®, Novartis) was licensed first in Italy …
Influenza vaccine: the challenge of antigenic drift
F Carrat, A Flahault - Vaccine, 2007 - Elsevier
Influenza continues to have a major worldwide impact, resulting in considerable human
suffering and economic burden. The regular recurrence of influenza epidemics is thought to …
suffering and economic burden. The regular recurrence of influenza epidemics is thought to …
Unmet needs in modern vaccinology: adjuvants to improve the immune response
G Leroux-Roels - Vaccine, 2010 - Elsevier
The key objective of vaccination is the induction of an effective pathogen-specific immune
response that leads to protection against infection and/or disease caused by that pathogen …
response that leads to protection against infection and/or disease caused by that pathogen …
Biology of immune responses to vaccines in elderly persons
B Weinberger, D Herndler-Brandstetter… - Clinical Infectious …, 2008 - academic.oup.com
With increasing age, the human immune system undergoes characteristic changes, termed
immunosenescence, which lead to increased incidence and severity of infectious diseases …
immunosenescence, which lead to increased incidence and severity of infectious diseases …
Vaccines for the elderly: current use and future challenges
B Weinberger - Immunity & ageing, 2018 - Springer
Age-related changes of the immune system contribute to increased incidence and severity of
infections in the elderly. Vaccination is the most effective measure to prevent infections and …
infections in the elderly. Vaccination is the most effective measure to prevent infections and …
Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza
VC Huber, RM McKeon, MN Brackin… - Clinical and vaccine …, 2006 - Am Soc Microbiol
Vaccination represents the most effective form of protection against influenza infection.
While neutralizing antibodies are typically measured as a correlate of vaccine-induced …
While neutralizing antibodies are typically measured as a correlate of vaccine-induced …
The adjuvanted influenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine
A Podda - Vaccine, 2001 - Elsevier
Elderly people and subjects with underlying chronic diseases are at increased risk for
influenza and related complications. Conventional influenza vaccines provide only limited …
influenza and related complications. Conventional influenza vaccines provide only limited …