Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

The mechanisms underlying the release of interleukin-1 (IL-1) family cytokines from
phagocytes have been the subject of intense investigations for more than 30 years. The …

Inflammasomes can prevent systemic dissemination of enteropathogenic bacteria. As
adapted pathogens including Salmonella Typhimurium (S. Tm) have evolved evasion …

The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway is
mainly responsible for the activation and release of a cascade of proinflammatory mediators …

Endotoxin—bacterial lipopolysaccharide (LPS)—is a driver of lethal infection sepsis through
excessive activation of innate immune responses. When delivered to the cytosol of …

Inflammation associated with gram‐negative bacterial infections is often instigated by the
bacterial cell wall component lipopolysaccharide (LPS). LPS‐induced inflammation and …

Highlights•NAIP/NLRC4 and Caspase-4/11 inflammasomes restrict S. Tm infection of gut
epithelium.•Importance of NAIP/NLRC4 versus Caspase-4/11 may shift between early and …

Inflammasomes are cytosolic innate immune complexes, which assemble in mammalian
cells in response to microbial components and endogenous danger signals. A major family …

Highlights•The pyrin inflammasome is triggered in response to RhoA inactivation.•Bacterial
effectors and toxins that inactivate RhoA vary in mechanism.•Pyrin-induced inflammation …

The major function of the mammalian immune system is to prevent and control infections
caused by enteropathogens that collectively have altered human destiny. In fact, as the …