Cocrystallization has been recognized as one of the most successful approaches to address
the stability problems of active pharmaceutical ingredients (APIs) in the past few decades …

Amorphization is one of the most effective pharmaceutical approaches to enhance the
dissolution and oral bioavailability of poorly water-soluble drugs. In recent years, amorphous …

The solid form of a pharmaceutical has a tremendous impact on its materials properties,
particularly solubility, dissolution rate, morphology, and tableting characteristics. Poor …

Preventing crystallization is a primary concern when developing amorphous drug
formulations. Recently, atomic layer coatings (ALCs) of aluminum oxide demonstrated …

Abstract Active Pharmaceutical Ingredients (APIs) do not always exhibit processable
physical properties, which makes their processing in an industrial setup very demanding …

Amorphous solid dispersions (ASDs) are a well-documented formulation approach to
improve the rate and extent of dissolution for hydrophobic pharmaceuticals. However …

Herein, we reported a new bergenin: 4-aminobenzamide (BGN-4AM) cocrystal with
significantly enhanced solubility and low hygroscopicity probed from two aspects such as …

Co-processing of APIs, the practice of creating multi-component APIs directly in chemical
processing facilities used to make drug substance, is gaining increased attention with a view …

The toolbox of methods for generating amorphous solid dispersions, which are often critical
to achieving high kinetic solubility and bioavailability of drug molecules, continues to grow …

Amorphous solid dispersions (ASDs) are an attractive option to improve the bioavailability of
poorly water-soluble compounds. However, the material attributes of ASDs can present …