Microfluidic Particle Engineering of Hydrophobic Drug with Eudragit E100─ Bridging the Amorphous and Crystalline Gap
Co-processing active pharmaceutical ingredients (APIs) with excipients is a promising
particle engineering technique to improve the API physical properties, which can lead to …
particle engineering technique to improve the API physical properties, which can lead to …
Improving dissolution performance and drug loading of amorphous dispersions through a hierarchical particle approach
Co-precipitation is an emerging manufacturing strategy for amorphous solid dispersions
(ASDs). Herein, the interplay between processing conditions, surface composition, and …
(ASDs). Herein, the interplay between processing conditions, surface composition, and …
[HTML][HTML] Formulation of ionic liquid APIs via spray drying processes to enable conversion into single and two-phase solid forms
E Tsolaki, MW Stocker, AM Healy… - International Journal of …, 2021 - Elsevier
Ionic liquid (IL) forms of drugs are increasingly being explored to address problems
presented by poorly water-soluble drugs and solid-state stability. However, before ILs of …
presented by poorly water-soluble drugs and solid-state stability. However, before ILs of …
Premix technologies for drug delivery: manufacturing, applications, and opportunities in regulatory filing
Active pharmaceutical ingredients (APIs) and excipients can be carefully combined in
premix-based materials before being added to dosage forms, providing a flexible platform …
premix-based materials before being added to dosage forms, providing a flexible platform …
Continuous manufacturing of small molecule solid oral dosage forms
J Wahlich - Pharmaceutics, 2021 - mdpi.com
Continuous manufacturing (CM) is defined as a process in which the input material (s) are
continuously fed into and transformed, and the processed output materials are continuously …
continuously fed into and transformed, and the processed output materials are continuously …
A co-processed API approach for a shear sensitive compound affording improved chemical stability and streamlined drug product processing
The physical properties of active pharmaceutical ingredients (API) are critical to both drug
substance (DS) isolation and drying operations, as well as streamlined drug product (DP) …
substance (DS) isolation and drying operations, as well as streamlined drug product (DP) …
Effect of organic acids on the solid-state polymorphic phase transformation of piracetam
F Fan, S Xu, M Guo, T Cai - International Journal of Pharmaceutics, 2023 - Elsevier
Metastable polymorphs are frequently used in oral solid dosage forms to enhance the
absorption of poorly water-soluble drug compounds. However, the solid phase …
absorption of poorly water-soluble drug compounds. However, the solid phase …
Comparing environmental impacts of direct compaction versus wet granulation tableting methods for drugs with poor flowability by life cycle assessment
Pharmaceutical tablet productions by direct compaction (DC) are more environmentally
sustainable than wet granulation (WG) owed to DC's lower energy consumption. For drug …
sustainable than wet granulation (WG) owed to DC's lower energy consumption. For drug …
FDA/M-CERSI co-processed API workshop proceedings
L Schenck, P Patel, R Sood, L Bonaga… - Journal of …, 2023 - Elsevier
These proceedings contain presentation summaries and discussion highlights from the
University of Maryland Center of Excellence in Regulatory Science and Innovation (M …
University of Maryland Center of Excellence in Regulatory Science and Innovation (M …
Control of drug-excipient particle attributes with droplet microfluidic-based extractive solidification enables improved powder rheology
Purpose Industrial implementation of continuous oral solid dosage form manufacturing has
been impeded by the poor powder flow properties of many active pharmaceutical …
been impeded by the poor powder flow properties of many active pharmaceutical …