In recent years, poorly water-soluble drug candidates in the drug development pipeline have
been a challenging issue for the pharmaceutical industry. Many delivery systems, such as …

Abstract Active Pharmaceutical Ingredients (APIs) do not always exhibit processable
physical properties, which makes their processing in an industrial setup very demanding …

Fenretinide (4-HPR), a retinoid derivative, has shown high antitumor activity, a low
toxicological profile, and no induction of resistance. Despite these favorable features, the …

Amorphous solid dispersions (ASDs) are a well-documented formulation approach to
improve the rate and extent of dissolution for hydrophobic pharmaceuticals. However …

Co-processing of APIs, the practice of creating multi-component APIs directly in chemical
processing facilities used to make drug substance, is gaining increased attention with a view …

The toolbox of methods for generating amorphous solid dispersions, which are often critical
to achieving high kinetic solubility and bioavailability of drug molecules, continues to grow …

Amorphous solid dispersions (ASDs) are an attractive option to improve the bioavailability of
poorly water-soluble compounds. However, the material attributes of ASDs can present …

Continuous direct compression (CDC) of solid oral dosage forms requires materials
exhibiting acceptable flow and compression properties. The desired active pharmaceutical …

Pharmaceutical cocrystals represent an emergent class of successful materials designed
based on crystal engineering principles, in which the limitations of the extant drugs are …

Purpose Precipitation of amorphous solid dispersions has gained traction in the
pharmaceutical industry given its application to pharmaceuticals with varying …