Recent advances in amorphous solid dispersions: preformulation, formulation strategies, technological advancements and characterization
Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for improvement of physical properties of pharmaceutical powders
C Jin, F Wu, Y Hong, L Shen, X Lin, L Zhao… - Carbohydrate Polymers, 2023 - Elsevier
Hydroxypropyl methylcellulose (HPMC) is an important polymeric excipient. Its versatility in
terms of molecular weights and viscosity grades is the basis for its wide and successful …
terms of molecular weights and viscosity grades is the basis for its wide and successful …
Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead …
MAM Subbaiah, J Rautio, NA Meanwell - Chemical Society Reviews, 2024 - pubs.rsc.org
The delivery of a drug to a specific organ or tissue at an efficacious concentration is the
pharmacokinetic (PK) hallmark of promoting effective pharmacological action at a target site …
pharmacokinetic (PK) hallmark of promoting effective pharmacological action at a target site …
The antisolvent coprecipitation method for enhanced bioavailability of poorly water-soluble drugs
J Zhang, M Liu, Z Zeng - International Journal of Pharmaceutics, 2022 - Elsevier
In recent years, poorly water-soluble drug candidates in the drug development pipeline have
been a challenging issue for the pharmaceutical industry. Many delivery systems, such as …
been a challenging issue for the pharmaceutical industry. Many delivery systems, such as …
The implications of drug-polymer interactions on the physical stability of amorphous solid dispersions
M Bookwala, PLD Wildfong - Pharmaceutical Research, 2023 - Springer
Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …
Continuous manufacturing and molecular modeling of pharmaceutical amorphous solid dispersions
Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-
soluble drugs. The escalating number of drugs with poor aqueous solubility, poor …
soluble drugs. The escalating number of drugs with poor aqueous solubility, poor …
Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
ALJ Khater, SH Almurisi, S Mahmood… - International Journal of …, 2023 - Elsevier
Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …
invasive, easy to administer, and easy to store. However, drug formulation for oral …
Early evaluation of opportunities in oral delivery of PROTACs to overcome their molecular challenges
Abstract PROteolysis TArgeting Chimeras (PROTACs) offer new opportunities in modern
medicine by targeting proteins that are intractable to classic inhibitors. Heterobifunctional in …
medicine by targeting proteins that are intractable to classic inhibitors. Heterobifunctional in …
Highly porous and drug-loaded amorphous solid dispersion microfiber scaffolds of indomethacin prepared by melt electrowriting
Melt electrowriting (MEW) is an additive manufacturing technology enabling the production
of highly porous microfiber scaffolds, suggested in particular for use in biomedical …
of highly porous microfiber scaffolds, suggested in particular for use in biomedical …
Preformulation study for the selection of a suitable polymer for the development of ellagic acid-based solid dispersion using hot-melt extrusion
I Nyamba, O Jennotte, CB Sombié, A Lechanteur… - International Journal of …, 2023 - Elsevier
Ellagic acid is one of the most studied polyphenolic compounds due to its numerous
promising therapeutic properties. However, this therapeutic potential remains difficult to …
promising therapeutic properties. However, this therapeutic potential remains difficult to …