Influenza A virus (IAV) infection represents a global threat causing seasonal outbreaks and
pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus …

Human brucellosis remains the commonest zoonotic disease worldwide with more than 500
000 new cases annually. Understanding the biology of Brucella infections and the …

Serious bacterial infections in immunocompromised patients require highly effective
antibacterial therapy for cure, and thus, this setting may reveal novel mechanisms by which …

To determine the potential for viral adaptation to T cell responses, we probed the full
influenza virus genome by next-generation sequencing directly ex vivo from infected mice, in …

Influenza is an infectious disease that primarily attacks the respiratory system. Innate
immunity provides both a very early defense to influenza virus invasion and an effective …

Emerging diseases are a major challenge to public health. Revealing the evolutionary
processes that allow novel pathogens to adapt to new hosts, also the potential barriers to …

Probable epidemic influenza outbreaks have been described as early as the 5th century BC,
as part of the Cough of Perinthus associated with the winter solstice, in Hippocrates' Corpus …

Influenza A viruses have sophisticated strategies to promote their own replication. Here, we
found that three H5N1 influenza viruses display different replication patterns in human A549 …

Myriad experiments have identified an important role for CD8+ T cell response mechanisms
in determining recovery from influenza A virus infection. Animal models of influenza infection …

Large outbreaks of zoonotic influenza A virus (IAV) infections may presage an influenza
pandemic. However, the likelihood that an airborne-transmissible variant evolves upon …