Structural modifications of polyethylenimine to control drug loading and release characteristics of amorphous solid dispersions
KN Kelsall, LM Foroughi, DS Frank… - Molecular …, 2023 - ACS Publications
Crystalline drugs with low solubility have the potential to benefit from delivery in the
amorphous form. The polymers used in amorphous solid dispersions (ASDs) influence their …
amorphous form. The polymers used in amorphous solid dispersions (ASDs) influence their …
Enhancing the Acidity of Polymers for Improved Stabilization of Amorphous Solid Dispersions: Protonation of Weakly Basic Compounds
KN Kelsall, RO Schubiner, L Schenck… - ACS Applied Polymer …, 2024 - ACS Publications
A cross-linked poly (vinylphosphonic acid)(PVPA) stabilizes compounds in amorphous solid
dispersions (ASDs). The performance of the polymer was compared to that of hydroxypropyl …
dispersions (ASDs). The performance of the polymer was compared to that of hydroxypropyl …
Densifying co-precipitated amorphous dispersions to achieve improved bulk powder properties
Purpose Precipitation of amorphous solid dispersions has gained traction in the
pharmaceutical industry given its application to pharmaceuticals with varying …
pharmaceutical industry given its application to pharmaceuticals with varying …
A Commentary on Co-Processed API as a Promising Approach to Improve Sustainability for the Pharmaceutical Industry
Pharmaceutical products represent a meaningful target for sustainability improvement and
emissions reduction. It is proposed here that rethinking the standard, and often linear …
emissions reduction. It is proposed here that rethinking the standard, and often linear …
Improving dissolution performance and drug loading of amorphous dispersions through a hierarchical particle approach
Co-precipitation is an emerging manufacturing strategy for amorphous solid dispersions
(ASDs). Herein, the interplay between processing conditions, surface composition, and …
(ASDs). Herein, the interplay between processing conditions, surface composition, and …
[HTML][HTML] Trends in amorphous solid dispersion drug products approved by the US Food and Drug Administration between 2012 and 2023
Abstract Forty-eight (48) drug products (DPs) containing amorphous solid dispersions
(ASDs) have been approved by the US Food and Drug Administration in the 12-year period …
(ASDs) have been approved by the US Food and Drug Administration in the 12-year period …
FDA/M-CERSI co-processed API workshop proceedings
L Schenck, P Patel, R Sood, L Bonaga… - Journal of …, 2023 - Elsevier
These proceedings contain presentation summaries and discussion highlights from the
University of Maryland Center of Excellence in Regulatory Science and Innovation (M …
University of Maryland Center of Excellence in Regulatory Science and Innovation (M …
Understanding Excipient-Induced Crystallization of Spray-Dried Amorphous Solid Dispersion
This study investigates the compatibility of excipients with the model system SDI-X and their
role in the induced crystallization of the amorphous compound-X in tablet formulations. We …
role in the induced crystallization of the amorphous compound-X in tablet formulations. We …