Vaccines are the most effective and cost-efficient method for preventing diseases caused by
infectious pathogens. Despite the great success of vaccines, development of safe and strong …

With very few adjuvants currently being used in marketed human vaccines, a critical need
exists for novel immunopotentiators and delivery vehicles capable of eliciting humoral …

Despite their obvious benefits, decades of research and hundreds of pre-clinical candidates,
only a handful of adjuvants are approved for prophylactic vaccination of humans. The slow …

The key objective of vaccination is the induction of an effective pathogen-specific immune
response that leads to protection against infection and/or disease caused by that pathogen …

Aluminum hydroxide (alum) and the oil-in-water emulsion MF59 are widely used, safe and
effective adjuvants, yet their mechanism of action is poorly understood. We assessed the …

The pure recombinant and synthetic antigens used in modern day vaccines are generally
less immunogenic than older style live/attenuated and killed whole organism vaccines. One …

Background The efficacy of inactivated influenza vaccines is known to be poor in infants and
young children. Methods We studied the effect of the adjuvant MF59, an oil-in-water …

For humans, companion animals, and food producing animals, vaccination has been touted
as the most successful medical intervention for the prevention of disease in the twentieth …

In preclinical studies, MF59 adjuvant offered improved protection against influenza virus
challenge and significantly reduced the viral load in the lungs of challenged mice. In …

More than 70 bacteria, viruses, parasites, and fungi are serious human pathogens. 1
Vaccines are available against some of these agents and are being developed against …