Age-related declines in immune response pose a challenge in combating diseases later in
life. Influenza (flu) infection remains a significant burden on older populations and often …

Background The relative vaccine effectiveness (rVE) of high-dose quadrivalent influenza
vaccines (QIV-HD) versus standard-dose quadrivalent influenza vaccines (QIV-SD) against …

Type 2 diabetes, obesity-related metabolic syndrome, and insulin resistance are the most
common metabolic disorders associated with increased cardiovascular risk. In addition …

Background Seasonal influenza may result in severe outcomes, resulting in a significant
increase of hospitalizations during the winter. To improve the protection provided by the …

Effective vaccine‐induced immune responses are particularly essential in older adults who
face an increased risk of immunosenescence. However, the complexity and variability of the …

Background Older adults are more vulnerable to seasonal influenza than younger adults.
The immune responses of older persons to the influenza vaccine are usually poorer than …

Abstract Background and Objective In Germany, influenza vaccination is mainly advised for
persons aged 60 years and over and individuals with health risks. Since 2021, an …

Influenza is associated with a substantial health burden, especially in high-risk subjects
such as older adults, frail individuals and those with underlying chronic diseases. In this …

After 40 years of its appearance, human immunodeficiency virus (HIV) infection remains a
leading public health challenge worldwide. Since the introduction of antiretroviral treatment …

Background A high-dose, split-virion inactivated quadrivalent influenza vaccine (IIV4-HD;
Sanofi) is being used for the prevention of influenza in multiple countries. This study …