Enhancing Immunogenicity of influenza vaccine in the elderly through intradermal vaccination: A literature analysis

HQ Quach, RB Kennedy - Viruses, 2022 - mdpi.com
Background: Aging and immunosenescence lead to a gradual decline in immune responses
in the elderly and the immunogenicity of influenza vaccines in this age group is sub-optimal …

Antibody titres elicited by the 2018 seasonal inactivated influenza vaccine decline by 3 months post‐vaccination but persist for at least 6 months

FL Mordant, OH Price, R Rudraraju… - Influenza and Other …, 2023 - Wiley Online Library
Abstract Background In Australia, seasonal inactivated influenza vaccine is typically offered
in April. However, the onset, peak and end of a typical influenza season vary, and optimal …

Relative effectiveness of MF59 adjuvanted trivalent influenza vaccine vs nonadjuvanted vaccines during the 2019–2020 influenza season

M Imran, J Puig-Barbera, JR Ortiz… - Open forum …, 2022 - academic.oup.com
Background Age-related immunosenescence may impair the immune response to
vaccination in older adults. Adjuvanted influenza vaccines are designed to overcome …

Immunogenicity of intramuscular MF59-adjuvanted and intradermal administered influenza enhanced vaccines in subjects aged over 60: a literature review

B Camilloni, M Basileo, S Valente… - Human vaccines & …, 2015 - Taylor & Francis
Because of the age-related immune system decline, 2 potentiated influenza vaccines were
specifically licensed for the elderly: Fluad®, an MF59-adjuvanted vaccine administered …

Seasonal influenza immunisation: strategies for older adults

W Schaffner, P van Buynder, S McNeil… - … journal of clinical …, 2018 - Wiley Online Library
Adults over the age of 60‐65 years suffer disproportionally from seasonal influenza,
experiencing high rates of complications, exacerbation of underlying medical comorbidities …

Systematic review of the efficacy, effectiveness and safety of MF59® adjuvanted seasonal influenza vaccines for the prevention of laboratory‐confirmed influenza in …

EO Murchu, L Comber, K Jordan… - Reviews in Medical …, 2023 - Wiley Online Library
The most effective means of preventing seasonal influenza is through vaccination. In this
systematic review, we investigated the efficacy, effectiveness and safety of MF59® …

[HTML][HTML] A phase 1, open-label, randomized study to compare the immunogenicity and safety of different administration routes and doses of virosomal influenza …

Y Levin, E Kochba, G Shukarev, S Rusch… - Vaccine, 2016 - Elsevier
Background Influenza remains a significant problem in elderly despite widespread
vaccination coverage. This randomized, phase-I study in elderly compared different …

[HTML][HTML] Immunogenicity of aIIV3, MF59-adjuvanted seasonal trivalent influenza vaccine, in older adults≥ 65 years of age: Meta-analysis of cumulative clinical …

U Nicolay, E Heijnen, P Nacci, PA Patriarca… - International Journal of …, 2019 - Elsevier
Objective Compare the immunogenicity of MF59-adjuvanted trivalent inactivated influenza
vaccine (aIIV3; Fluad™) versus conventional trivalent inactivated influenza vaccine (IIV3) in …

Comparison of the immunogenicity and safety of the conventional subunit, MF59-adjuvanted, and intradermal influenza vaccines in the elderly

YB Seo, WS Choi, J Lee, JY Song… - Clinical and vaccine …, 2014 - Am Soc Microbiol
The influenza vaccination is known as the most effective method for preventing influenza
infection and its complications in the elderly. Conventional subunit (Agrippal S1; Novartis) …

Superior antigen-specific CD4+T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older

RB Couch, JM Bayas, C Caso, IN Mbawuike… - BMC infectious …, 2014 - Springer
Background The effectiveness of trivalent influenza vaccines may be reduced in older
versus younger adults because of age-related immunosenescence. The use of an adjuvant …