Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

Background There is an urgent need for improved influenza vaccines especially for older
adults due to the presence of immunosenescence. It is therefore highly relevant to compare …

Older adults, defined as those≥ 60 years of age, are a growing population vulnerable to
infections including severe acute respiratory syndrome coronavirus 2. Although …

Background. The elderly, commonly defined as subjects aged≥ 65 years, are among the at-
risk subjects recommended for annual influenza vaccination in European countries …

Objectives MF59-adjuvanted standard-dose and nonadjuvanted high-dose seasonal
influenza vaccines have been developed to protect the elderly at high risk of severe …

The adaptation of influenza seed viruses in egg culture can result in a variable antigenic
vaccine match each season. The cell-based quadrivalent inactivated influenza vaccine …

Individuals aged 65 years and above are at increased risk of complications and death from
influenza compared with any other age group. Enhanced vaccines, as the MF59® …

Vaccine efficacy determined within the controlled environment of a clinical trial is usually
substantially greater than real-world vaccine effectiveness. Typically, this results from …

The effectiveness of seasonal influenza vaccination (SIV) varies from year to year. Interim
estimates of vaccine effectiveness (VE) in outpatient settings have suggested that the …

Background: When new vaccine components or platforms are developed, they will typically
need to demonstrate noninferiority or superiority over existing products, resulting in the …