Currently, organic crystal structure prediction (CSP) methods are based on searching for the
most thermodynamically stable crystal structure, making various approximations in …

Generally speaking, molecular compounds have a strong tendency to have crystalline order
in the solid state. Amorphous materials do exist, of course, but they are rarely the most stable …

This Tutorial Review, aimed at both the novice and the seasoned solid-state chemist,
provides a succinct overview of key findings that have, over the last half century, advanced …

Forces to reckon with: Supramolecular complexes, such as the one shown, are normally
based on a combination of different interactions such as ion pairing, hydrogen bonds, and …

The general goal of drug discovery is to identify novel compounds that are active against a
preselected biological target with acceptable pharmacological properties defined by …

The reliability of solvent drop grinding (SDG), also referred to as liquid assisted grinding, wet
cogrinding, or mechanochemistry, to facilitate cocrystal formation is addressed with a series …

Abstract Knowledge of the oxidation state of metal centres in compounds and materials
helps in the understanding of their chemical bonding and properties. Chemists have …

The design and synthesis of crystalline materials through the self-assembly of molecular
building blocks and the pursuit of functional materials based upon this approach are usually …

Based on torsion angle distributions of frequently occurring substructures, conformation
preferences of druglike molecules are presented, accompanied by a review of the relevant …

Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of
numerous cytokines and growth factors involved in the regulation of immunity, inflammation …